The importance of HLA-G is documented by the fact that there are more than 2 500 papers on HLA-G and Google returns more than 7,5 million entries related to this molecule.
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Obviously, the present pandemic provides a strong impetus to deeper studies on mechanisms of pathologies caused by various respiratory viruses. Better understanding of this area may bring entirely novel approaches to prevention and therapy of diseases caused by such pathogens. Here we present a short communication of Prof. Vaclav Horejsi, PhD (IMG AS CR) on this Hot Topic.
Mouse monoclonal antibody Ki-67 has become an important tool in tumor diagnostics and cancer studies for its ability to identify proliferating cells.
Fragmentation of DNA during apoptosis excludes apoptotic sperms from ability to give a life to a baby.
When performing immunostaining procedures, it is important to know also the backround signal of the immunoglobulin itself, especially when higher antibody concentrations are being used. Hence negative controls represented by conjugates of corresponding antibody isotypes are available.
Easy way how to identify regulatory T cells (Tregs) in human peripheral blood or umbilical cord blood.
Recombinant allergens are produced both in prokaryotic (mainly E. coli) and in eukaryotic (yeast and insect cells) expression systems and in addition to their use in diagnostics find their way also into immunotherapy of various allergies.
The mouse monoclonal antibody JOVI.1, recognizing an extracellular epitope on TCR Cbeta1 (TRBC1), is suitable for flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections). It is popular as a tool for analysis of T cell-mediated diseases.