Alpha-beta T cell receptors (TCRs) are antigen specific receptors, which are essential to the immune response and are present on the cell surface of T lymphocytes. They recognize peptide-loaded major histocompatibility complexes (pMHCs) that are displayed by antigen presenting cells (APCs). Binding of alpha-beta TCR to pMHC initiates TCR-CD3 clustering on the cell surface and initiates the T cell effector functions. FIG. 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human TCR Cbeta1 (JOVI.1) FITC antibody (4 μl reagent / 100 μl of peripheral whole blood). Currently available formats:
Comming soon formats:
Today we bring an extension to the Notch topics presented in previous blog.
Notch signaling represents one of the cornerstones of the immune system.
Anti-human CD38 clones HB7 and HIT2 were compared regarding their reactivity with particular blood cell populations.