Alpha-beta T cell receptors (TCRs) are antigen specific receptors, which are essential to the immune response and are present on the cell surface of T lymphocytes. They recognize peptide-loaded major histocompatibility complexes (pMHCs) that are displayed by antigen presenting cells (APCs). Binding of alpha-beta TCR to pMHC initiates TCR-CD3 clustering on the cell surface and initiates the T cell effector functions.
FIG. 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human TCR Cbeta1 (JOVI.1) FITC antibody (4 μl reagent / 100 μl of peripheral whole blood).
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We are proud to inform you that in March 2020 in Cytometry B (Clinical cytometry) a paper was released having one of our colleagues from EXBIO Praha team Miro Benko (Director, Product Development Department) as a co-author.
Recently developed strategy for prevention of cancer relapse due to acquired radioresistance may be based on immunotherapies. One promising approach is based on genetically modified T cells expressing chimeric antigen receptors (CAR).