JOVI.1 - popular anti-TCR clone available now in EXBIO portfolio

The mouse monoclonal antibody JOVI.1, recognizing an extracellular epitope on TCR Cbeta1 (TRBC1), is suitable for flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections). It is popular as a tool for analysis of T cell-mediated diseases.

Alpha-beta T cell receptors (TCRs) are antigen specific receptors, which are essential to the immune response and are present on the cell surface of T lymphocytes. They recognize peptide-loaded major histocompatibility complexes (pMHCs) that are displayed by antigen presenting cells (APCs). Binding of alpha-beta TCR to pMHC initiates TCR-CD3 clustering on the cell surface and initiates the T cell effector functions.

FIG. 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human TCR Cbeta1 (JOVI.1) FITC antibody (4 μl reagent / 100 μl of peripheral whole blood).

Currently available formats:

Comming soon formats:

  • PE
  • APC


Would you like to have it in other formats? Let us know!