Exbio — Research products — Antibodies — Microbiology and virology — Anti-Tb10.4 (M. tuberculosis) Purified

Anti-Tb10.4 (M. tuberculosis) Purified

Regulatory status

RUO

Antigen

Tb10.4 (M. tuberculosis)

Clone

PAb (186)

Format

Purified

Reactivity

Mycobacterium tuberculosis

Application

ELISA, WB

Variant

0.1 mg

11-186-C100

In stock

198.00 USD

Variant

0.1 mg

11-186-C100

In stock

198.00 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Rabbit polyclonal

Specificity

The rabbit polyclonal antibody to Tb10.4 reacts with Mycobacterium tuberculosis protein Tb10.4 (EsxH).

Application

ELISA, WB

Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Tb10.4 protein produced in E. coli

Concentration

1 mg/ml

Preparation

Purified by ligand affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

Rv0288, EsxH

Antigen description

The Mycobacterium tuberculosis antigen Tb10.4, also known as EsxH, Rv0288, ESAT-6 like protein EsxH, or Cfp7, is a conserved bacterial protein which effectively induces immune response to M. tuberculosis infection. It is a promissing vaccination tool.

Entrez Gene ID 886603

UniProt ID P9WNK3

General references:

Billeskov R, Vingsbo-Lundberg C, Andersen P, Dietrich J: Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1. J Immunol. 2007 Sep 15;179(6):3973-81.
PubMed

Skjøt RL, Brock I, Arend SM, Munk ME, Theisen M, Ottenhoff TH, Andersen P: Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family. Infect Immun. 2002 Oct;70(10):5446-53.
PubMed

Skjøt RL, Oettinger T, Rosenkrands I, Ravn P, Brock I, Jacobsen S, Andersen P: Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens. Infect Immun. 2000 Jan;68(1):214-20.
PubMed

Dietrich J, Aagaard C, Leah R, Olsen AW, Stryhn A, Doherty TM, Andersen P: Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy. J Immunol. 2005 May 15;174(10):6332-9.
PubMed