Exbio — Research products — Antibodies — Microbiology and virology — Anti-ESAT-6 (M. tuberculosis) Purified

Anti-ESAT-6 (M. tuberculosis) Purified

Anti-ESAT-6 (M. tuberculosis) Purified
Regulatory status
RUO
Antigen
ESAT-6 (M. tuberculosis)
Clone
PAb (491)
Format
Purified
Reactivity
Mycobacterium tuberculosis
Application
WB
Variant
0.1 mg
11-491-C100
In stock
180.00 USD
0.025 mg
11-491-C025
Delivery 1 week
90.00 USD
Variant
0.1 mg
11-261-C100
In stock
180.00 USD
0.1 mg
11-261-C100
In stock
90.00 USD
Contact distributor
Product details
Description
References
Isotype
Rabbit polyclonal
Specificity
The rabbit polyclonal antibody to EsaT-6 recognizes the EsaT-6 (Rv3875) protein of Mycobacterium tuberculosis and Mycobacterium bovis.
Application
WB
Application details
Western blotting: Recommended dilution 0.5-1 μg/ml, reducing conditions.
Reactivity
Mycobacterium tuberculosis
Immunogen
EsaT-6 (Rv3875) of Mycobacterium tuberculosis
Concentration
1 mg/ml
Preparation
Purified from rabbit serum by affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
ESXA, ESAT-6, Rv3875
Antigen description
The Mycobacterium tuberculosis antigen EsaT-6 (6 kDa early secretory antigen target EsxA ) causes induction of neutrophil necrosis. This protein acts as a leukocidin, which may facilitate bacterial avoidance of the antimicrobial action of the immune system.
Entrez Gene ID 886209
UniProt ID P9WNK7

General references:

Francis RJ, Butler RE, Stewart GR: Mycobacterium tuberculosis ESAT-6 is a leukocidin causing Ca2+ influx, necrosis and neutrophil extracellular trap formation. Cell Death Dis. 2014 Oct 16;5:e1474.
PubMed
Arlehamn CS, Sidney J, Henderson R, Greenbaum JA, James EA, Moutaftsi M, Coler R, McKinney DM, Park D, Taplitz R, Kwok WW, Grey H, Peters B, Sette A: Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ). J Immunol. 2012 May 15;188(10):5020-31.
PubMed
Variant
0.1 mg
11-491-C100
In stock
180.00 USD
0.025 mg
11-491-C025
Delivery 1 week
90.00 USD
Variant
0.1 mg
11-261-C100
In stock
180.00 USD
0.1 mg
11-261-C100
In stock
90.00 USD
Contact distributor
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