Exbio — Research products — Antibodies — Microbiology and virology — Anti-Acr1 (M. tuberculosis) Purified

Anti-Acr1 (M. tuberculosis) Purified

Regulatory status

RUO

Antigen

Acr1 (M. tuberculosis)

Clone

PAb (185)

Format

Purified

Reactivity

Mycobacterium tuberculosis

Application

ELISA, WB

Variant

0.1 mg

11-185-C100

In stock

198.00 USD

Variant

0.1 mg

11-185-C100

In stock

198.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Rabbit polyclonal

Specificity

The rabbit polyclonal antibody to Acr1 reacts with Mycobacterium tuberculosis protein Acr1 (Rv2031c, Hsp16.3).

Application

ELISA, WB

Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Acr1 protein (produced in E. coli)

Concentration

1 mg/ml

Preparation

Purified by ligand affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

Hsp16.3

Antigen description

The Mycobacterium tuberculosis antigen Acr1 (alpha-crystallin-related protein 1), also known as Hsp16.3, is a small heat shock protein (16 kDa), which forms oligomeric assemblies. Expression of Acr1 is induced by exposure to hypoxia or nitric oxide and is associated with bacterial persistence in a non-replicating state.

Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen Acr1. A) cell lysate of non-transfected E. coli B) cell lysate of Acr1-transfected E. coli

General references:

Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJ: Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med. 2012 Aug 15;186(4):369-77
PubMed

Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280(39):33419-25.
PubMed