Exbio — Research products — Antibodies — Nucleus — Anti-CRP Biotin

Anti-CRP Biotin

Anti-CRP Biotin
Regulatory status
RUO
Antigen
CRP
Clone
C7
Format
Biotin
Reactivity
Human
Application
ELISA
Variant
0.1 mg
1B-484-C100
In stock
270.00 USD
Variant
0.1 mg
11-261-C100
In stock
270.00 USD
Contact distributor
Product details
Description
References
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody C7 recognizes human CRP, a 117 kDa acute phase protein; it detects the antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
Application
ELISA
Reactivity
Human
Immunogen
Purified human CRP
Concentration
1 mg/ml
Preparation
Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Antigen description
The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein composed of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
Entrez Gene ID 1401
UniProt ID P02741

General references:

van der Harst P, Voors AA, Volbeda M, Buikema H, van Veldhuisen DJ, van Gilst WH: Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting. Am J Cardiol. 2006 Jun 15;97(12):1697-701.
PubMed
Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2007 Jan 15;22(6):973-9.
PubMed

Product specific references:

Krämer PM, Kess M, Kremmer E, Schulte-Hostede S: Multi-parameter determination of TNFα, PCT and CRP for point-of-care testing. Analyst. 2011 Feb 21;136(4):692-5.
PubMed
Variant
0.1 mg
1B-484-C100
In stock
270.00 USD
Variant
0.1 mg
11-261-C100
In stock
270.00 USD
Contact distributor
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