Michaela Novakova, M.D., Ph.D.
LinkedIn / OrcidID
Department of Paediatric Haematology and Oncology
Charles University and University Hospital Motol
Trop-2 is thought to be associated with the epithelial phenotype of cancer cells and many studies have reported that epithelial markers positively correlate with its expression, whereas mesenchymal markers typically exert negative correlation.
Cytokeratins are a subfamily of intermediate filaments and are characterized by remarkable biochemical diversity. Among other applications, they also can be used as markers for detection and characterization of circulating tumor cells.