Exbio — Research products — Antibodies — Microbiology and virology — Anti-Acr2 (M. tuberculosis) Purified

Anti-Acr2 (M. tuberculosis) Purified

Regulatory status

RUO

Antigen

Acr2 (M. tuberculosis)

Clone

PAb (188)

Format

Purified

Reactivity

Mycobacterium tuberculosis

Application

ELISA, WB

Variant

0.1 mg

11-188-C100

Ask for delivery term HERE

198.00 USD

Variant

0.1 mg

11-188-C100

Ask for delivery term HERE

198.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Rabbit polyclonal

Specificity

The rabbit polyclonal antibody to Acr2 reacts with Mycobacterium tuberculosis protein Acr2 (Rv0251c, Hsp20).

Application

ELISA, WB

Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Acr2 protein (produced in E. coli)

Concentration

1 mg/ml

Preparation

Purified by ligand affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

Hsp20, HrpA

Antigen description

The Mycobacterium tuberculosis antigen Acr2 (alpha-crystallin-related protein 2), also known as HrpA or Hsp20, is a small heat shock protein, which forms oligomeric assemblies. Expression of Acr2 is induced by heat shock, oxidative stress, and uptake by macrophages. It evokes a vigorous early immune response.

Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen Acr2. A) cell lysate of non-transfected E. coli B) cell lysate of Acr2-transfected E. coli

General references:

Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB: The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 2005 Feb;55(4):1127-37.
PubMed

Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ: Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 2005 Apr 1;174(7):4237-43.
PubMed

Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280(39):33419-25.
PubMed