Exbio — Research products — Antibodies — Serum, plasma, and secreted proteins — Anti-Thyroglobulin Purified

Anti-Thyroglobulin Purified

Regulatory status

RUO

Antigen

Thyroglobulin

Clone

2H11

Format

Purified

Reactivity

Human

Application

IHC-P

Variant

0.1 mg

11-466-C100

In stock

143.00 USD

0.025 mg

11-466-C025

Delivery 1 week

71.50 USD

Variant

0.1 mg

11-466-C100

In stock

143.00 USD

0.025 mg

11-466-C025

Delivery 1 week

71.50 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG1

Specificity

The antibody 2H11 recognizes thyroglobulin (TG), a 610 kDa extracellular secreted glycoprotein specific to the thyroid gland. TG is mainly expressed on thyroid follicular cells (99,1 %).

Application

IHC-P

Application details

Immunohistochemistry (paraffin sections): Recommended dilution: 1:80 - 1:100; pretreatment: heat retrieval in 0.01M citrate buffer, pH 6 (microwave oven); positive tissue: thyroid gland, follicular adenoma.

Reactivity

Human

Immunogen

thyroid follicular cells

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

TG, TGN, AITD3

Antigen description

Thyroid disorders are often associated with autoimmune diseases and thyroid cancer.

Entrez Gene ID 7038

UniProt ID P01266

General references:

Lazar V, Bidart JM, Caillou B, Mahe C, Lacroix L, Filetti S, Schlumberger M: Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab. 1999 Sep;84(9):3228-34.
PubMed

Emerson CH, Torres MS: Recombinant human thyroid-stimulating hormone: pharmacology, clinical applications and potential uses. BioDrugs. 2003;17(1):19-38. Review.
PubMed

Hishinuma A, Takamatsu J, Ohyama Y, Yokozawa T, Kanno Y, Kuma K, Yoshida S, Matsuura N, Ieiri T: Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. J Clin Endocrinol Metab. 1999 Apr;84(4):1438-44.
PubMed

Product specific references:

Magro G, Perissinotto D, Schiappacassi M, Goletz S, Otto A, Müller EC, Bisceglia M, Brown G, Ellis T, Grasso S, Colombatti A, Perris R: Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas. Am J Pathol. 2003 Jul;163(1):183-96.
PubMed