Exbio — Research products — Antibodies — Serum, plasma, and secreted proteins — Anti-Lactoferrin Purified

Anti-Lactoferrin Purified

Regulatory status

RUO

Antigen

Lactoferrin

Clone

LF5-1D2

Format

Purified

Reactivity

Human

Application

ELISA, FC (QC tested)

Variant

0.1 mg

11-128-C100

In stock

143.00 USD

0.025 mg

11-128-C025

Delivery 1 week

71.50 USD

Variant

0.1 mg

11-128-C100

In stock

143.00 USD

0.025 mg

11-128-C025

Delivery 1 week

71.50 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Mouse IgG1

Specificity

The mouse monoclonal antibody LF5-1D2 recognizes lactoferrin, an iron-binding secreted glycoprotein of about 90 kDa, which has anti-inflammatory, immunomodulatory and anti-microbial properties.

Application

ELISA, FC (QC tested)

Application details

Flow cytometry: Recommended dilution: 1-4 µg/ml. Intracellular staining.

Reactivity

Human

Immunogen

human lactoferrin

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

LF, Lactotransferrin, LTF

Antigen description

Lactoferrin is an iron-binding glycoprotein of the transferrin family, which is released to most biological fluids, with particularly high levels in milk. It has anti-inflammatory (e.g. sequestering of lipopolysaccharides), anti-microbial (e.g. blocking of viral attachment to the target cell), and immunomodulatory properties and can prevent infections in young children. Lactoferrin is considered to bridge the innate and adaptive immune responses. It also participates in iron homeostasis, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Besides biological fluids it is also found in the secondary granules of neutrophils.

Entrez Gene ID 4057

UniProt ID P02788

Flow cytometry analysis (intracellular staining) of human peripheral blood cells using anti-lactoferrin (LF5-1D2) purified, GAM-APC.

General references:

Turin CG, Zea-Vera A, Pezo A, Cruz K, Zegarra J, Bellomo S, Cam L, Llanos R, Castañeda A, Tucto L, Ochoa TJ; NEOLACTO Research Group: Lactoferrin for prevention of neonatal sepsis. Biometals. 2014 Oct;27(5):1007-16. doi: 10.1007/s10534-014-9754-3.
PubMed

Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q: Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35(5):557-66.
PubMed

Product specific references:

Zwirzitz A, Reiter M, Skrabana R, Ohradanova-Repic A, Majdic O, Gutekova M, Cehlar O, Petrovčíková E, Kutejova E, Stanek G, Stockinger H, Leksa V: Lactoferrin is a natural inhibitor of plasminogen activation. J Biol Chem 2018; 293(22) 8600-8613
PubMed