Exbio — Research products — Antibodies — Serum, plasma, and secreted proteins — Anti-Insulin Purified Low Endotoxin

Anti-Insulin Purified Low Endotoxin

Regulatory status

RUO

Antigen

Insulin

Clone

IN-05

Format

Purified Low Endotoxin

Reactivity

Pig, Cow, Human

Application

ELISA, RIA, IHC-P, ICC, FUNC

Variant

0.1 mg

12-246-C100

In stock

143.00 USD

Variant

0.1 mg

12-246-C100

In stock

143.00 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG1

Specificity

The antibody IN-05 reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma.

Application

ELISA, RIA, IHC-P, ICC, FUNC

Application details

Functional application: The antibody IN-05 blocks binding of insulin to the receptor.

Reactivity

Pig, Cow, Human

Immunogen

Porcine insulin.

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

IDDM, INS

Antigen description

Insulin and glucagon are pancreatic endocrine hormones secreted by islet cells within the pancreas. The stimulus for insulin secretion is a HIGH blood glucose. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population.

Entrez Gene ID 3630

UniProt ID P01308

Product specific references:

Horejsi V, Hilgert I, Kristofova H, Satayalai O: Murine hybridoma monoclonal antibodies against insulin: cross-reactivity with insulins of three species and blocking of insulin binding to its receptor. Immunol Lett. 1984;8(5):279-83.
PubMed