Anti-Hu IL-17A Purified

Anti-Hu IL-17A Purified
Regulatory status
RUO
Antigen
IL-17A
Clone
9F9
Format
Purified
Reactivity
Human
Variant
0.1 mg
11-937-C100
In stock
160.00 USD
Variant
0.1 mg
11-937-C100
In stock
160.00 USD
Product details
Description
Images
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody 9F9 recognizes human interleukin 17A (IL-17A; secreted or intracellular).
Application details
Flow cytometry: Recommended dilution: 0.5-4 µg/ml. Intracellular staining.
Reactivity
Human
Immunogen
mammalian-derived human IL-17-IgG fusion protein, boost with recombinant human IL-17A
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
Interleukin 17
Antigen description
Interleukin 17A (IL-17A) is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. It plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. It is the signature effector cytokine of Th17 cells, and in this role it primarily induces neutrophil activation and recruitment at infection and inflammatory sites. High levels of IL-17A are associated with rheumatoid arthritis, psoriasis, multiple sclerosis, and another inflammatory diseases, including lung injugy during severe COVID 19. This cytokine also contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. It is an effector cytokine for invariant NKT cells (iNKT), and it is involved in epithelial barrier formation upon injury.
Entrez Gene ID 3605
UniProt ID Q16552
11-937_FC_Profil Značení
Flow cytometry intracellular staining pattern of human PHA stimulated and Brefeldin A treated peripheral whole blood stained using anti-human IL-17A (9F9) purified antibody (concentration in sample 0,5 μg/ml, GAM APC).
11-937_FC_Dot-plot
Flow cytometry multicolor intracellular staining of PHA stimulated and Brefeldin A treated peripheral whole blood showing lymphocytes stained using anti-human CD4 (MEM-241) PE-Cy™7 antibody (4 μl reagent / 100 μl of peripheral whole blood) and anti-human IL-17A (9F9) purified antibody (concentration in sample 0,5 μg/ml, GAM APC).
11-937_FC_Histogram
Separation of human CD4 positive IL-17A positive lymphocytes (red-filled) from CD4 negative IL-17A negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human PHA stimulated and Brefeldin A treated peripheral whole blood stained using anti-human IL-17A (9F9) purified antibody (concentration in sample 0,5 μg/ml, GAM APC).
Variant
0.1 mg
11-937-C100
In stock
160.00 USD
Variant
0.1 mg
11-937-C100
In stock
160.00 USD

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