Anti-Hu IgM Purified

Anti-Hu IgM Purified
Regulatory status
RUO
Antigen
IgM
Clone
MA2
Format
Purified
Reactivity
Human
Application
Variant
0.1 mg
11-321-C100
In stock
100.00 USD

0.025 mg
11-321-C025
Delivery 1 week
50.00 USD
Variant
0.1 mg
11-261-C100
In stock
100.00 USD

0.1 mg
11-261-C100
In stock
50.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG2b
Specificity
The antibody MA2 reacts with µ-chain of human IgM, Fab - region localized epitope.
Application
Reactivity
Human
Immunogen
IgM from human serum.
Concentration
1 mg/ml
Preparation
Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
Formulation
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
immunoglobulin M
Antigen description
Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.
11-321_ELISA
ELISA analysis of IgM in human serum using capture antibody MA2 and HRP-conjugated detection antibody CH2. Three different dilutions of human serum were used, and 10% BSA as negative control.

General references:

Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95.
PubMed
Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71.
PubMed
Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34.
PubMed
Brinkmann V, Heusser CH: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32.
PubMed

Product specific references:

Maerle AV, Simonova MA, Pivovarov VD, Voronina DV, Drobyazina PE, Trofimov DY, Alekseev LP, Zavriev SK, Ryazantsev DY: Development of the covalent antibody-DNA conjugates technology for detection of IgE and IgM antibodies by immuno-PCR. PLoS One 2019 Jan 4;14(1):e0209860.
PubMed
Variant
0.1 mg
11-321-C100
In stock
100.00 USD

0.025 mg
11-321-C025
Delivery 1 week
50.00 USD
Variant
0.1 mg
11-261-C100
In stock
100.00 USD

0.1 mg
11-261-C100
In stock
50.00 USD