Exbio — Research products — Antibodies — Serum, plasma, and secreted proteins — Anti-Hu Ig Lambda Light Chain Purified

Anti-Hu Ig Lambda Light Chain Purified

Regulatory status

RUO

Antigen

Ig Lambda Light Chain

Clone

1-155-2

Format

Purified

Reactivity

Human

Application

FC (QC tested)

Variant

0.1 mg

11-673-C100

In stock

150.00 USD

0.025 mg

11-673-C025

Delivery 1 week

75.00 USD

Variant

0.1 mg

11-673-C100

In stock

150.00 USD

0.025 mg

11-673-C025

Delivery 1 week

75.00 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG1 kappa

Specificity

The mouse monoclonal antibody 1-155-2 recognizes lambda light chains (22.5 kDa) of human immunoglobulin.

Application

FC (QC tested)

Application details

Flow cytometry: Recommended dilution: 1-4 μg/ml. Extracellular and intracellular staining.

Reactivity

Human

Immunogen

Human IgA1 lambda myeloma protein

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

Immunoglobulin lambda, Igl

Antigen description

Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda; both having a molecular weight of 22.5kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.

General references:

Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95.
PubMed

Product specific references:

Kubagawa H, Gathings WE, Levitt D, Kearney JF, Cooper MD: Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence. J Clin Immunol. 1982 Oct;2(4):264-9.
PubMed

Bahler DW, Pindzola JA, Swerdlow SH: Splenic marginal zone lymphomas appear to originate from different B cell types. Am J Pathol. 2002 Jul;161(1):81-8.
PubMed

Tierens AM, Holte H, Warsame A, Ikonomou IM, Wang J, Chan WC, Delabie J: Low levels of monoclonal small B cells in the bone marrow of patients with diffuse large B-cell lymphoma of activated B-cell type but not of germinal center B-cell type. Haematologica. 2010 Aug;95(8):1334-41.
PubMed