Anti-Hu Ig Lambda Light Chain APC-Cy™7

Anti-Hu Ig Lambda Light Chain APC-Cy™7
Regulatory status
RUO
Antigen
Ig Lambda Light Chain
Clone
1-155-2
Format
APC-Cy™7
Reactivity
Human
Application
Excitation laser
red (633 nm)
Variant
100 tests
T4-673-T100
In stock
275.00 USD

25 tests
T4-673-T025
Delivery 1 week
137.50 USD
Variant
100 tests
T4-673-T100
In stock
275.00 USD

25 tests
T4-673-T025
Delivery 1 week
137.50 USD
Product details
Description
Images
References
SDS download
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody 1-155-2 recognizes lambda light chains (22.5 kDa) of human immunoglobulin.
Application
Application details
Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Extracellular and intracellular staining.
Reactivity
Human
Immunogen
Human IgA1 lambda myeloma protein
Preparation
Purified antibody is conjugated with activated tandem dye of allophycocyanin-cyanine 7 (APC-Cy™7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Licence note
Cy™ and CyDye™ are registered trademarks of Cytiva.
Other names
Immunoglobulin lambda, Igl
Antigen description
Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda; both having a molecular weight of 22.5kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.
T4-673 FC
Flow cytometry analysis (surface staining) of lambda light chains in human peripheral blood with anti-lambda light chains (1-155-2) APC-Cy™7.

General references:

Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95.
PubMed

Product specific references:

Kubagawa H, Gathings WE, Levitt D, Kearney JF, Cooper MD: Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence. J Clin Immunol. 1982 Oct;2(4):264-9.
PubMed
Bahler DW, Pindzola JA, Swerdlow SH: Splenic marginal zone lymphomas appear to originate from different B cell types. Am J Pathol. 2002 Jul;161(1):81-8.
PubMed
Tierens AM, Holte H, Warsame A, Ikonomou IM, Wang J, Chan WC, Delabie J: Low levels of monoclonal small B cells in the bone marrow of patients with diffuse large B-cell lymphoma of activated B-cell type but not of germinal center B-cell type. Haematologica. 2010 Aug;95(8):1334-41.
PubMed
Variant
100 tests
T4-673-T100
In stock
275.00 USD

25 tests
T4-673-T025
Delivery 1 week
137.50 USD
Variant
100 tests
T4-673-T100
In stock
275.00 USD

25 tests
T4-673-T025
Delivery 1 week
137.50 USD

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