Anti-SOCS3 Purified

Anti-SOCS3 Purified
Regulatory status
RUO
Antigen
SOCS3
Clone
SO1
Format
Purified
Reactivity
Human
Application
WB
Variant
0.1 mg
11-406-C100
In stock

0.025 mg
11-406-C025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock
Product details
Images
References
Isotype
Mouse IgG2b
Specificity
The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.
Application
WB
Reactivity
Human
Immunogen
Full-length SOCS3 protein.
Other names
SOCS-3, CIS3, SSI3
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Exbio licence note
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic use. In vivo diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s. © 2019 EXBIO Praha, a.s. All rights reserved.
11-406 WB
Western blotting analysis (reducing conditions) of whole cell lysate of HeLa human cervix carcinoma cell line. Lane 1: immunostaining with Isotype mouse IgG2b control (PLRV219; cat. no. 11-801-C100) Lane 2: immunostaining with anti-SOCS3 (SO1)

General references:

Miao T, Wu D, Zhang Y, Bo X, Xiao F, Zhang X, Magoulas C, Subang MC, Wang P, Richardson PM: SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. Mol Cell Neurosci. 2008 Feb;37(2):367-75.
PubMed
Elliott J: SOCS3 in Liver Regeneration and Hepatocarcinoma. Mol Interv. 2008 Feb;8(1):19-21.
PubMed
Zhu BM, Ishida Y, Robinson GW, Pacher-Zavisin M, Yoshimura A, Murphy PM, Hennighausen L. SOCS3 Negatively Regulates the gp130-STAT3 Pathway in Mouse Skin Wound Healing. J Invest Dermatol. 2008 Jan 10
PubMed
Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20;279(8):6905-10.
PubMed
Yu CR, Mahdi RM, Ebong S, Vistica BP, Gery I, Egwuagu CE: Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells. J Biol Chem. 2003 Aug 8;278(32):29752-9.
PubMed

Product specific references:

Neuwirt H, Puhr M, Cavarretta IT, Mitterberger M, Hobisch A, Culig Z: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. Endocr Relat Cancer. 2007 Dec;14(4):1007-19.
PubMed
Variant
0.1 mg
11-406-C100
In stock

0.025 mg
11-406-C025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock