Anti-PDK1 Purified

Anti-PDK1 Purified
Regulatory status
RUO
Antigen
PDK1
Clone
PAb (659)
Format
Purified
Reactivity
Human
Application
WB
Variant
0.1 mg
11-659-C100
In stock
Variant
0.1 mg
11-261-C100
In stock
Product details
References
Isotype
Rabbit polyclonal
Specificity
The rabbit polyclonal antibody recognizes PDK1, a serine/threonine proteinkinase of 63 kDa, which is a central activator of multiple signaling pathways coupled to a large number of growth-promoting stimuli.
Application
WB
Reactivity
Human
Immunogen
Peptide corresponding to the amino acids CIQEVWRQRYQSHPDAAVQ of human PDK1
Other names
PDPK1
Concentration
0.5 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Exbio licence note
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic use. In vivo diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s. © 2019 EXBIO Praha, a.s. All rights reserved.

General references:

Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S: PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science. 2005 Apr 1;308(5718):114-8.
PubMed
Egawa K, Maegawa H, Shi K, Nakamura T, Obata T, Yoshizaki T, Morino K, Shimizu S, Nishio Y, Suzuki E, Kashiwagi A: Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes. J Biol Chem. 2002 Oct 11;277(41):38863-9.
PubMed
Scheid MP, Parsons M, Woodgett JR: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol. 2005 Mar;25(6):2347-63.
PubMed
Alajajian BB, Fletcher L, Isgor E, Jimenez DF, Digicaylioglu M: IGF-I regulated phosphorylation and translocation of PDK-1 in neurons. Neuroreport. 2009 Apr 22;20(6):579-83.
PubMed
Variant
0.1 mg
11-659-C100
In stock
Variant
0.1 mg
11-261-C100
In stock