Exbio — Research products — Antibodies — Other intracellular antigens — Anti-NTAL Purified

Anti-NTAL Purified

Regulatory status

RUO

Antigen

NTAL

Clone

PAb (486)

Format

Purified

Reactivity

Mouse

Application

Variant

0.1 mg

11-486-C100

Ask for delivery term HERE

198.00 USD

0.025 mg

11-486-C025

Delivery 1 week

99.00 USD

Variant

0.1 mg

11-486-C100

Ask for delivery term HERE

198.00 USD

0.025 mg

11-486-C025

Delivery 1 week

99.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Rabbit polyclonal

Specificity

The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.

Application

Application details

Western blotting: Recommended dilution: 1 μg/ml; positive control: murine spleen; non-reducing conditions.

Reactivity

Mouse

Negative species

Human

Immunogen

Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.

Concentration

1 mg/ml

Preparation

Purified by ligand affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

LAB, LAT2

Antigen description

NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.

Entrez Gene ID 7462

UniProt ID Q9GZY6

Western blotting analysis (non-reducing conditions) of mouse NTAL in mouse spleen tissue. Lane 1: immunostaining with polyclonal anti-NTAL antibody (cat. no. 11-487-C100) Lane 2: immunostaining with polyclonal anti-mouse NTAL antibody (specific for N-terminal domain of mouse NTAL)

Product specific references:

Volná P, Lebduška P, Dráberová L, Šímová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):1001-13.
PubMed