Exbio — Research products — Antibodies — Other intracellular antigens — Anti-LRRC32 Purified

Anti-LRRC32 Purified

Anti-LRRC32 Purified
Regulatory status
RUO
Antigen
LRRC32
Clone
GARP5
Format
Purified
Reactivity
Human
Application
WB
Variant
0.1 mg
11-744-C100
In stock
130.00 USD
0.025 mg
11-744-C025
Delivery 1 week
65.00 USD
Variant
0.1 mg
11-744-C100
In stock
130.00 USD
0.025 mg
11-744-C025
Delivery 1 week
65.00 USD
Contact distributor
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody GARP5 recognizes GARP / LRRC32, an approximately 80 kDa glycoprotein expressed e.g. on the surface of megakaryocytes, platelets and activated Treg cells.
Application
WB
Application details
Western blotting: Recommended dilution: 1-2 μg/ml; positive control: human thrombocytes, reducing conditions
Reactivity
Human
Immunogen
Purified human sGARP protein
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
GARP, D11S833E
Antigen description
GARP (glycoprotein A repetitions predominant protein), also known as garpin or LRRC32 (leucin-rich repeat containing protein 32) is an approximately 80 kDa transmembrane glycoprotein detected on the surface of megakaryocytes, platelets, and activated Treg cells. It binds to the latency-associated peptide (LAP) domain of pro-TGF beta and regulates its storage and activation. The expression of GARP on Treg cells seems to be necessary for their suppressive functions.
Entrez Gene ID 2615
UniProt ID Q14392
11-744 WB
Western blotting analysis (reducing conditions) of GARP antigen and its degradatory products in lysate of human thrombocytes by anti-GARP monoclonal antibody (GARP5).

Product specific references:

Wang R, Zhu J, Dong X, Shi M, Lu C, Springer TA: GARP regulates the bioavailability and activation of TGFβ. Mol Biol Cell. 2012 Mar;23(6):1129-39
PubMed
Variant
0.1 mg
11-744-C100
In stock
130.00 USD
0.025 mg
11-744-C025
Delivery 1 week
65.00 USD
Variant
0.1 mg
11-744-C100
In stock
130.00 USD
0.025 mg
11-744-C025
Delivery 1 week
65.00 USD
Contact distributor
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