Exbio — Research products — Antibodies — Other intracellular antigens — Anti-Hu Tomm34 Purified

Anti-Hu Tomm34 Purified

Regulatory status

RUO

Antigen

Tomm34

Clone

Tomm34-4.1

Format

Purified

Reactivity

Human

Application

IP, WB, ICC

Variant

0.1 mg

11-891-C100

In stock

198.00 USD

Variant

0.1 mg

11-891-C100

In stock

198.00 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG1

Specificity

The mouse monoclonal antibody Tomm34-4.1 recognizes an epitope within TPR2 domain of human Tomm34 protein.

Application

IP, WB, ICC

Reactivity

Human

Immunogen

Recombinant human Tomm34

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

URCC3, HTOM34P

Antigen description

Tomm34 (translocase of the outer mitochondrial membrane 34) is an additional component of the cellular chaperone system involved in protein folding. As the name suggests, Tomm34 was initially identified as being involved in mitochondrial protein processing. Subsequent studies have shown that Tomm34 interacts with both Hsp70 and Hsp90 and modifies their protein folding activities. In cancer, high levels of Tomm34 have been reported in bladder, colorectal and breast cancers compared to their normal tissue counterparts. In these cancers, Tomm34 promotes colorectal cancer cell growth and is a biomarker of poor outcome in early invasive breast cancer and bladder cancer. As a tumour-associated protein, Tomm34 peptide vaccination is under investigation as a therapeutic option for colorectal cancer, with significant Tomm34 cytotoxic T-lymphocyte (CTL) response observed.

Entrez Gene ID 10953

UniProt ID Q15785

Product specific references:

Müller P, Coates PJ, Nenutil R, Trčka F, Hrstka R, Chovanec J, Brychtová V, Vojtěšek B: Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage. J Ovarian Res. 2019 Mar 27;12(1):30.
PubMed