Exbio — Research products — Antibodies — Nucleus — Anti-TAp63 Purified

Anti-TAp63 Purified

Regulatory status

RUO

Antigen

TAp63

Clone

TAp63-4.1

Format

Purified

Reactivity

Mouse, Rat, Human

Application

IP, WB, IHC(P), ICC

Variant

0.1 mg

11-890-C100

In stock

198.00 USD

Variant

0.1 mg

11-890-C100

In stock

198.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Mouse IgG2a

Specificity

The mouse monoclonal antibody TAp63-4.1 recognizes TAp63; target epitope LSDPMW. This antibody does not bind to deltaNp63 isoform of p63.

Application

IP, WB, IHC(P), ICC

Application details

Western blotting: Recommended dilution: 1 μg/ml

Reactivity

Mouse, Rat, Human

Immunogen

Recombinant human p63

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

AIS, KET, LMS, NBP, RHS, EEC3, OFC8, SHFM4

Antigen description

The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63, do not cross-react with the related p53 and p73 proteins, and allow for discrimination between p63 isoforms TAp63 and deltaNp63 with opposite functional properties.

Entrez Gene ID 8626

UniProt ID Q9H3D4

Western blotting analysis, confirming specificity of mouse monoclonal antibody TAp63-4.1 for TAp63 isoform of p63 protein. Cell lysates from particular transfectants of TAp63alpha, TAp63gamma, deltaNp63alpha, TAp73alpha, and deltaNp73alpha were analysed.

Product specific references:

Nekulová M, Holčáková J, Nenutil R, Stratmann R, Bouchalová P, Müller P, Mouková L, Coates PJ, Vojtěšek B: Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry. Virchows Arch. 2013 Sep;463(3):415-25.
PubMed