Anti-TAp63 Purified

Anti-TAp63 Purified
Regulatory status
RUO
Antigen
TAp63
Clone
TAp63-4.1
Format
Purified
Reactivity
Mouse, Rat, Human
Variant
0.1 mg
11-890-C100
In stock
180.00 USD
Variant
0.1 mg
11-261-C100
In stock
180.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG2a
Specificity
The mouse monoclonal antibody TAp63-4.1 recognizes TAp63; target epitope LSDPMW. This antibody does not bind to deltaNp63 isoform of p63.
Application details
Western blotting: Recommended dilution: 1 μg/ml
Reactivity
Mouse, Rat, Human
Immunogen
Recombinant human p63
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
AIS, KET, LMS, NBP, RHS, EEC3, OFC8, SHFM4
Antigen description
The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63, do not cross-react with the related p53 and p73 proteins, and allow for discrimination between p63 isoforms TAp63 and deltaNp63 with opposite functional properties.
Entrez Gene ID 8626
UniProt ID Q9H3D4
11-890_WB
Western blotting analysis, confirming specificity of mouse monoclonal antibody TAp63-4.1 for TAp63 isoform of p63 protein. Cell lysates from particular transfectants of TAp63alpha, TAp63gamma, deltaNp63alpha, TAp73alpha, and deltaNp73alpha were analysed.

Product specific references:

Nekulová M, Holčáková J, Nenutil R, Stratmann R, Bouchalová P, Müller P, Mouková L, Coates PJ, Vojtěšek B: Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry. Virchows Arch. 2013 Sep;463(3):415-25.
PubMed
Variant
0.1 mg
11-890-C100
In stock
180.00 USD
Variant
0.1 mg
11-261-C100
In stock
180.00 USD