Exbio — Research products — Antibodies — Nucleus — Anti-Hu deltaNp73 Purified

Anti-Hu deltaNp73 Purified

Regulatory status

RUO

Antigen

deltaNp73

Clone

DNp73-1.1

Format

Purified

Reactivity

Human

Application

IP, WB, ICC

Variant

0.1 mg

11-889-C100

In stock

203.50 USD

Variant

0.1 mg

11-889-C100

In stock

203.50 USD

Contact distributor

Product details

Description

Images

SDS download

Isotype

Mouse IgG1

Specificity

The mouse monoclonal antibody DNp73-1.1 recognizes human deltaNp73; target epitope is MLYVGDPARHLAT.

Application

IP, WB, ICC

Application details

Western blotting: Recommended dilution: 1 μg/ml

Reactivity

Human

Immunogen

KLH-coupled synthetic peptide MLYVGDPARHLATC

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

p73 DN

Antigen description

The p53 family of proteins includes three members, p53, p63, and p73. The protein p73 is encoded by TP73 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp73) or absence (deltaNp73) of an N-terminal transactivation domain. Investigations have been hampered by a lack of well characterized antibodies that are specific for p73 and do not cross-react with the related p53 and p63 proteins, as well as a lack of antibodies that specifically recognize either the TAp73 or deltaNp73 variants. We are introducing now such a set of antibodies.

Entrez Gene ID 7161

UniProt ID O15350

Western blotting analysis of p73 isoforms using mouse monoclonal antibody DNp73-1.1. This antibody is suitable for distinguishing between them. It detected specifically deltaNp73 isoform in H1299/deltaNp73 transfectants, whereas it ignored TAp73 isoform in H1299/TAp73 transfectants.