Exbio — Research products — Antibodies — Nucleus — Anti-HDAC6 Purified

Anti-HDAC6 Purified

Regulatory status

RUO

Antigen

HDAC6

Clone

2H3

Format

Purified

Reactivity

Human

Application

ELISA, ICC

Variant

0.1 mg

11-839-C100

In stock

140.00 USD

Variant

0.1 mg

11-839-C100

In stock

140.00 USD

Contact distributor

Product details

Description

Images

References

Isotype

Mouse IgG1 kappa

Specificity

The mouse monoclonal antibody 2H3 recognizes D1 domain of human histone deacetylase 6 (HDAC6; intracellular antigen), amino acids 281-291. Crossreactivity with other species was not tested.

Application

ELISA, ICC

Application details

Immunocytochemistry: Recommended dilution: 5-10 μg/ml.

Reactivity

Human

Immunogen

human HDAC6

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

Histone deacetylase 6

Antigen description

Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.

Entrez Gene ID 10013

UniProt ID Q9NSW6

Immunocytochemistry staining of HDAC6 in formaldehyde-fixed and Triton-permeabilized HEK-293T cells by mouse monoclonal antibody 2H3, followed by anti-mouse Alexa Fluor 488 (green), DNA indicated by DAPI (blue).