Anti-BCL6 Purified

Anti-BCL6 Purified
Regulatory status
RUO
Antigen
BCL6
Clone
IG191E/A8
Format
Purified
Reactivity
Mouse, Human
Variant
0.1 mg
11-867-C100
In stock
180.00 USD
Variant
0.1 mg
11-261-C100
In stock
180.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody IG191E/A8 recognizes BCL6, a transcriptional repressor serving as a master regulator of germinal center reaction.
Application details
Flow cytometry: Recommended dilution: 1-4 µg/ml. Intracellular staining.
Reactivity
Mouse, Human
Immunogen
pCDNA3 plasmid containing full-length sequence of human BCL6
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
LAZ3, ZNF51, ZBTB27
Antigen description
BCL6 is a zinc finger-containing transcription factor, which acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. On B cells, BCL6 induces proliferation, antibody class switching and affinity maturation, whereas it inhibits their differentiation into plasma cells. On T cells, BCL6 induces their differentiation into T-FH cells.
Entrez Gene ID 604
UniProt ID P41182
11-867_FC_Profil značení
Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human BCL6 (IG191E/A8) purified antibody (concentration in sample 5 μg/ml, GAM APC).
11-867_FC_Histogram
Separation of monocytes stained anti-human BCL6 (IG191E/A8) purified antibody (concentration in sample 5 μg/ml, GAM APC, red-filled) from monocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (intracellular staining)

Product specific references:

Jain S, Stock A, Macian F, Putterman C: A Distinct T follicular helper cell subset infiltrates the brain in murine neuropsychiatric lupus. Front Immunol. 2018 Mar 13;9:487.
PubMed
Hoser D, Schön C, Loddenkemper C, Lohneis P, Kühl AA, Sommermann T, Blankenstein T, Willimsky G: Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice. Blood. 2018 Aug 30;132(9):924-934.
PubMed
Tan HX, Esterbauer R, Vanderven HA, Juno JA, Kent SJ, Wheatley AK: Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice. Front Immunol. 2019 Mar 29;10:611.
PubMed
Jiang W, Wragg KM, Tan HX, Kelly HG, Wheatley AK, Kent SJ, Juno JA: Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay. J Immunol Methods. 2019 Apr;467:48-57.
PubMed
Variant
0.1 mg
11-867-C100
In stock
180.00 USD
Variant
0.1 mg
11-261-C100
In stock
180.00 USD

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