Anti-HLA Class I Purified

Anti-HLA Class I Purified
Regulatory status
RUO
Antigen
HLA Class I
Clone
MEM-81
Format
Purified
Reactivity
Human
Application
Variant
0.1 mg
11-243-C100
In stock
143.00 USD

0.025 mg
11-243-C025
Delivery 1 week
71.50 USD
Variant
0.1 mg
11-243-C100
In stock
143.00 USD

0.025 mg
11-243-C025
Delivery 1 week
71.50 USD
Product details
Description
Images
References
SDS download
Isotype
Mouse IgG1
Specificity
The antibody MEM-81 reacts with an extracellular epitope on human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.
Application
Application details
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Reactivity
Human
Immunogen
Leukocytes of a patient suffering with LGL type leukemia.
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Antigen description
HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
11-243_FC_Profil Značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-HLA Class I (MEM-81) purified antibody (concentration in sample 1 μg/ml) GAM APC.
11-243_FC_Histogram
Separation of human leukocytes stained using anti-HLA Class I (MEM-81) purified antibody (concentration in sample 1 μg/ml, GAM APC, red-filled) from human leukocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Valenzuela NM, Mulder A, Reed EF: HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcγRs. J Immunol. 2013 Jun 15;190(12):6635-50.
PubMed
Variant
0.1 mg
11-243-C100
In stock
143.00 USD

0.025 mg
11-243-C025
Delivery 1 week
71.50 USD
Variant
0.1 mg
11-243-C100
In stock
143.00 USD

0.025 mg
11-243-C025
Delivery 1 week
71.50 USD

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