Exbio — Research products — Antibodies — Cytoskeleton and ECM — Anti-RLTPR PE

Anti-RLTPR PE

Anti-RLTPR PE
Regulatory status
RUO
Antigen
RLTPR
Clone
EM-53
Format
PE
Reactivity
Mouse, Human
Application
FC (QC tested)
Excitation laser
blue (488 nm)
Variant
0.1 mg
1P-718-C100
In stock
340.00 USD
0.025 mg
1P-718-C025
In stock
170.00 USD
Variant
0.1 mg
11-261-C100
In stock
340.00 USD
0.1 mg
11-261-C100
In stock
170.00 USD
Contact distributor
Product details
Images
References
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody EM-53 recognizes RLTPR / CARMIL2, an intracellular protein playing a role in actin filament elongation.
Application
FC (QC tested)
Reactivity
Mouse, Human
Immunogen
Murine RLTPR
Other names
CARMIL2, LRRC16C
Concentration
0.1 mg/ml
Preparation
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide
Storage and handling
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
1P-718 FC
Separation of RLTPR transfected cells stained using anti-RLTPR (EM-53) PE antibody (concentration in sample 27 μg/ml, red) from unstained RLTPR transfected cells (black) in flow cytometry analysis (intracellular staining).

General references:

Schober T, Magg T, Laschinger M, Rohlfs M, Linhares ND, Puchalka J, Weisser T, Fehlner K, Mautner J, Walz C, Hussein K, Jaeger G, Kammer B, Schmid I, Bahia M, Pena SD, Behrends U, Belohradsky BH, Klein C, Hauck F: A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017 Jan 23;8:14209.
PubMed

Product specific references:

Wang Y, Ma CS, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, Payne K, Crestani E, Roncagalli R, Belkadi A, Kerner G, Lorenzo L, Deswarte C, Chrabieh M, Patin E, Vincent QB, Müller-Fleckenstein I, Fleckenstein B, Ailal F, Quintana-Murci L, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Puel A, Bustamante J, Boisson-Dupuis S, Malissen M, Malissen B, Abel L, Hovnanian A, Notarangelo L, Jouanguy E, Tangye SG, Béziat V, Casanova JL: Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med. 2016 Oct 17;213(11):2413-2435.
PubMed
Roncagalli R, Cucchetti M, Jarmuzynski N, Grégoire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchánek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M4, Malissen B: The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016 Oct 17;213(11):2437-2457.
PubMed
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, Wülfing C, Malissen B, Malissen M: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66.
PubMed
Variant
0.1 mg
1P-718-C100
In stock
340.00 USD
0.025 mg
1P-718-C025
In stock
170.00 USD
Variant
0.1 mg
11-261-C100
In stock
340.00 USD
0.1 mg
11-261-C100
In stock
170.00 USD
Contact distributor
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