Anti-Lamin C Purified

Anti-Lamin C Purified
Regulatory status
RUO
Antigen
Lamin C
Clone
EM-11
Format
Purified
Reactivity
Human, Mouse
Application
IP, WB, ICC
Variant
0.1 mg
11-563-C100
In stock

0.025 mg
11-563-C025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock
Product details
Images
References
Isotype
Mouse IgG2a
Specificity
The mouse monoclonal antibody EM-11 recognizes lamin C, intermediate filament protein of nuclear lamina.
Application
IP, WB, ICC
Reactivity
Human, Mouse
Other names
LMNC
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Exbio licence note
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic use. In vivo diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s. © 2019 EXBIO Praha, a.s. All rights reserved.
11-563_ICC
Immunocytochemistry staining of lamin C (red) in HeLa cells by monoclonal antibody EM-11. Actin decorated by phalloidin-Alexa Fluor® 488 (green), DNA stained by DAPI (blue).
11-563_ICC_2
Immunocytochemistry staining of lamin C (green) in mouse EL-6 fibroblasts by monoclonal antibody EM-11. DNA stained by DAPI (blue).

General references:

Cortés R, Roselló-Lletí E, Rivera M, Martínez-Dolz L, Azorín I, Salvador A, Portolés M: The role of the nuclear lamins in the pathogenesis of heart failure in patients undergoing cardiac transplantation. Transplant Proc. 2009 Jul-Aug;41(6):2227-30.
PubMed
Chen S, Martin C, Maya-Mendoza A, Tang CW, Lovrić J, Sims PF, Jackson DA: Reduced Expression of Lamin A/C Results in Modified Cell Signaling and Metabolism Coupled with Changes in Expression of Structural Proteins. J Proteome Res. 2009 Oct 15. [Epub ahead of print]
PubMed
Saga A, Karibe A, Otomo J, Iwabuchi K, Takahashi T, Kanno H, Kikuchi J, Keitoku M, Shinozaki T, Shimokawa H: Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. Tohoku J Exp Med. 2009 Aug;218(4):309-16.
PubMed
Mounkes LC, Burke B, Stewart CL: The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases. Trends Cardiovasc Med. 2001 Oct;11(7):280-5.
PubMed

Product specific references:

Shimi T, Kittisopikul M, Tran J, Goldman AE, Adam SA, Zheng Y, Jaqaman K, Goldman RD: Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy. Mol Biol Cell. 2015 Nov 5;26(22):4075-86.
PubMed
Variant
0.1 mg
11-563-C100
In stock

0.025 mg
11-563-C025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock