Anti-GFAP Purified

Anti-GFAP Purified
Regulatory status
RUO
Antigen
GFAP
Clone
GA-5
Format
Purified
Reactivity
Pig, Human, Rat
Application
IP, WB, IHC(P), ICC
Variant
0.1 mg
11-583-C100
In stock

0.025 mg
11-583-C025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock
Product details
References
Isotype
Mouse IgG1
Specificity
The antibody GA-5 reacts with GFAP, the principal marker of astroglial cells in the central nervous system, which is specifically expressed in satellite cells in peripheral ganglia and in non myelinating Schwann cells in peripheral nerves. The GFAP protein runs on gels at ~55 kDa protein, usually associated with lower Mw bands which are thought to be proteolytic fragments and alternate transcripts from the single gene.
Application
IP, WB, IHC(P), ICC
Reactivity
Pig, Human, Rat
Immunogen
Porcine spinal cord
Other names
Glial fibrillary acidic protein, GFAP, ALXDRD
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Exbio licence note
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic use. In vivo diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s. © 2019 EXBIO Praha, a.s. All rights reserved.

General references:

Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A: Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet. 2001 Jan;27(1):117-20.
PubMed

Product specific references:

Rungger-Brändle E, Dosso AA, Leuenberger PM: Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1971-80.
PubMed
Guillemin GJ, Wang L, Brew BJ: Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex. J Neuroinflammation. 2005 Jul 26;2:16.
PubMed
Joardar A, Sen AK, Das S: Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes. J Lipid Res. 2006 Mar;47(3):571-81.
PubMed
Triviño A, Ramírez JM, Ramírez AI, Salazar JJ, García-Sanchez J: Retinal perivascular astroglia: an immunoperoxidase study. Vision Res. 1992 Sep;32(9):1601-7.
PubMed
Perng MD, Cairns L, van den IJssel P, Prescott A, Hutcheson AM, Quinlan RA: Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin. J Cell Sci. 1999 Jul;112 ( Pt 13):2099-112.
PubMed
Variant
0.1 mg
11-583-C100
In stock

0.025 mg
11-583-C025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock