Exbio — Research products — Antibodies — Cytoskeleton and ECM — Anti-Cytokeratin 7 Alexa Fluor<sup>®</sup> 488

Anti-Cytokeratin 7 Alexa Fluor^® 488

Regulatory status

RUO

Antigen

Cytokeratin 7

Clone

OV-TL 12/30

Format

Alexa Fluor^® 488

Reactivity

Human

Application

IHC-F, IHC-P

Excitation laser

blue (488 nm)

test1 True

Variant

0.1 mg

A4-958-C100

In stock

248.60 USD

Variant

0.1 mg

A4-958-C100

In stock

248.60 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG1 kappa

Specificity

The mouse monoclonal antibody OVTL12 recognizes cytokeratin 7, an intermediate filament protein.

Application

IHC-F, IHC-P

Reactivity

Human

Immunogen

OTNII ovarian carcinoma cell line

Concentration

0.1 mg/ml

Preparation

Purified antibody is conjugated with Alexa Fluor^® 488 NHS ester under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Formulation

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Alexa Fluor^®, Pacific Blue™ and Pacific Orange™ are registered trademarks of Life Technologies Corporation.

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com.

Other names

K7, CK7, CYK7, KRT7, SCL, K2C7

Antigen description

Cytokeratins are a subfamily of intermediate filaments and are characterized by remarkable biochemical diversity. They are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.

Entrez Gene ID 3855

UniProt ID P08729

Product specific references:

van Niekerk CC, Boerman OC, Ramaekers FC, Poels LG: Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas. Am J Pathol. 1991 Feb;138(2):455-63.
PubMed

Torenbeek R, Lagendijk JH, Van Diest PJ, Bril H, van de Molengraft FJ, Meijer CJ: Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma. Histopathology 1998 Jan;32(1):20-7.
PubMed

van Niekerk CC, Vooijs P, Casparie-van Velsen IJ, Poels LG: Differentiation margins of ovarian tumor pathology: First incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev. 1997;21(3):247-57.
PubMed

van Niekerk CC, Jap PH, Ramaekers FC, van de Molengraft F, Poels LG: Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues. J Pathol. 1991 Oct;165(2):145-52.
PubMed

Ramaekers F, van Niekerk C, Poels L, Schaafsma E, Huijsmans A, Robben H, Schaart G, Vooijs P: Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am J Pathol. 1990 Mar;136(3):641-55.
PubMed