Anti-Ms CD8b Purified

Anti-Ms CD8b Purified
Regulatory status
RUO
Antigen
CD8b
Clone
H35-17.2
Format
Purified
Reactivity
Mouse
Variant
0.1 mg
11-779-C100
In stock
130.00 USD

0.025 mg
11-779-C025
Delivery 1 week
65.00 USD
Variant
0.1 mg
11-261-C100
In stock
130.00 USD

0.1 mg
11-261-C100
In stock
65.00 USD
Product details
Description
Images
References
Isotype
Rat IgG2b kappa
Specificity
The rat monoclonal antibody H35-17.2 recognizes an extracellular epitope of mouse CD8b, the 32-34 kDa beta chain of the CD8 coreceptor, expressed on cytotoxic T cells and thymocytes.
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Mouse
Immunogen
Mouse CD8b
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
Ly-3, Ly-C, Lyt-3
Antigen description
The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
UniProt ID P10300
11-779 FC
Flow cytometry analysis (surface staining) of murine splenocytes using anti-CD8b (H35-17.2) purified, DAR-APC.

Product specific references:

Cooney LA, Gupta M, Thomas S, Mikolajczak S, Choi KY, Gibson C, Jang IK, Danziger S, Aitchison J, Gardner MJ, Kappe SH, Wang R: Short-lived effector CD8 T cells induced by genetically attenuated malaria parasite vaccination express CD11c. Infect Immun. 2013 Nov;81(11):4171-81
PubMed
Weici Zhang, Masanobu Tsuda, Guo-Xiang Yang, Koichi Tsuneyama, Xiao-Song He, Aftab A. Ansari, William M. Ridgway, Ross L. Coppel, Zhe-Xiong Lian, Patrick S.C. Leung, M. Eric Gershwin: Lymphoma-Like T Cell Infiltration in Liver Is Associated with Increased Copy Number of Dominant Negative Form of TGFβ Receptor II. PLoS One. 2012; 7(11): e49413.
PubMed
Henderson AJ, Kumar A, Barnett B, Dow SW, Ryan EP: Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal Lactobacillus spp. J Med Food. 2012 May;15(5):469-75.
PubMed
Krieg C, Boyman O, Fu YX, Kaye J: B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation. Nat Immunol. 2007 Feb;8(2):162-71.
PubMed
Chaudhary N, Datta K, Askin FB, Staab JF, Marr KA: Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation. Am J Respir Crit Care Med. 2012 Feb 1;185(3):301-10.
PubMed
Rubin B, Riond J, Leghait J, Gairin JE: Interactions between CD8alphabeta and the TCRalphabeta/CD3-receptor complex. Scand J Immunol. 2006 Sep;64(3):260-70.
PubMed
Variant
0.1 mg
11-779-C100
In stock
130.00 USD

0.025 mg
11-779-C025
Delivery 1 week
65.00 USD
Variant
0.1 mg
11-261-C100
In stock
130.00 USD

0.1 mg
11-261-C100
In stock
65.00 USD

Related products

-134%
CloneRTG2B1-2
Reg. statusRUO
0.1 mg
105.00 USD