Anti-Ms CD49d PE

Anti-Ms CD49d PE
Regulatory status
RUO
Antigen
CD49d
Clone
R1-2
Format
PE
Reactivity
Mouse
Application
Excitation laser
blue (488 nm)
Variant
0.1 mg
1P-734-C100
Ask for delivery term HERE
132.00 USD
Variant
0.1 mg
1P-734-C100
Ask for delivery term HERE
132.00 USD
Product details
Description
Images
References
SDS download
Isotype
Rat IgG2b kappa
Specificity
The rat monoclonal antibody R1-2 recognizes an extracellular epitope of murine CD49d / Integrin alpha 4 (VLA-4 alpha), an approximately 150 kDa glycoprotein of the integrin family, expressed on multiple blood cell types.
Application
Application details
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Reactivity
Mouse
Immunogen
murine T lymphoma line TK1
Concentration
0.5 mg/ml
Preparation
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
Itga4, Vla-4 alpha
Antigen description
CD49d (integrin alpha 4), also known as very late antigen 4 alpha (VLA-4 alpha) is a cell surface glycoprotein constituting integrin complexes. CD49d heterodimerizes with CD29 (integrin beta 1) to form VLA-4 antigen, which is involved in cell-cell and cell-extracellular matrix interactions, which is a receptor for CD106 (VCAM) and fibronectin. CD79d also heterodimerizes with integrin beta 7 to form LPAM-1, which binds to MAdCAM-1 (mucosal vascular addressin). These interactions are important for cell adhesion and activation.
Entrez Gene ID 16401
UniProt ID Q00651
1P-734-FC_Profil značení
Flow cytometry analysis surface staining pattern of murine splenocyte suspension stained using anti-mouse CD49d (R1-2) PE antibody (concentration in sample 5 μg/ml).
1P-734-FC_Histogram
Separation of murine CD49d positive cells (red-filled) from unstained sample (black-dashed) in flow cytometry analysis (surface staining) of murine splenocyte suspension stained using anti-mouse CD49d (R1-2) PE antibody (concentration in sample 5 μg/ml).

Product specific references:

Zhu X, Nishimura F, Sasaki K, Fujita M, Dusak JE, Eguchi J, Fellows-Mayle W, Storkus WJ, Walker PR, Salazar AM, Okada H: Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
PubMed
Sadahira Y, Yasuda T, Yoshino T, Manabe T, Takeishi T, Kobayashi Y, Ebe Y, Naito M: Impaired splenic erythropoiesis in phlebotomized mice injected with CL2MDP-liposome: an experimental model for studying the role of stromal macrophages in erythropoiesis. J Leukoc Biol. 2000 Oct;68(4):464-70.
PubMed
Cheung DS, Ehlenbach SJ, Kitchens RT, Riley DA, Thomas LL, Holtzman MJ, Grayson MH: Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J Immunol. 2010 Nov 1;185(9):4983-7.
PubMed
Geutskens SB, Nikolic T, Dardenne M, Leenen PJ, Savino W: Defective up-regulation of CD49d in final maturation of NOD mouse macrophages. Eur J Immunol. 2004 Dec;34(12):3465-76.
PubMed
Lin J, Qin L, Chavin KD, Ding Y, Punch JD, Yang Q, Burkly LC, Bromberg JS: CD3 and CD2 ligation alters CD49d epitope expression. Pathobiology. 1995;63(3):119-32.
PubMed
Variant
0.1 mg
1P-734-C100
Ask for delivery term HERE
132.00 USD
Variant
0.1 mg
1P-734-C100
Ask for delivery term HERE
132.00 USD

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