Anti-Ms CD26 Purified

Anti-Ms CD26 Purified
Regulatory status
RUO
Antigen
CD26
Clone
H194-112
Format
Purified
Reactivity
Mouse
Variant
0.1 mg
11-776-C100
In stock
90.00 USD

0.025 mg
11-776-C025
Delivery 1 week
45.00 USD
Variant
0.1 mg
11-261-C100
In stock
90.00 USD

0.1 mg
11-261-C100
In stock
45.00 USD
Product details
Description
Images
References
Isotype
Rat IgG2a kappa
Specificity
The rat monoclonal antibody H194-112 recognizes an extracellular epitope of CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Mouse
Immunogen
BALB/c thymocytes
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
DPP4, TP103, ADCP-2, ADABP
Antigen description
CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
Entrez Gene ID 13482
UniProt ID P28843
11-776 FC
Separation of murine splenocytes stained using anti-mouse CD26 (H194-112) purified antibody (concentration in sample 4 μg/ml, DAR APC, red-filled) from murine splenocytes unstained by primary antibody (DAR APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Niedermeyer J, Kriz M, Hilberg F, Garin-Chesa P, Bamberger U, Lenter MC, Park J, Viertel B, Püschner H, Mauz M, Rettig WJ, Schnapp A: Targeted disruption of mouse fibroblast activation protein. Mol Cell Biol. 2000 Feb;20(3):1089-94.
PubMed
James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D, Simpson E, Cardozo L, Warrens A, Szydlo RM, Lechler RI, Marelli-Berg FM: Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood. 2003 Sep 15;102(6):2173-9.
PubMed
Dorrell C, Erker L, Lanxon-Cookson KM, Abraham SL, Victoroff T, Ro S, Canaday PS, Streeter PR, Grompe M: Surface markers for the murine oval cell response. Hepatology. 2008 Oct;48(4):1282-91.
PubMed
Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N: Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9.
PubMed
Adams S, Miller GT, Jesson MI, Watanabe T, Jones B, Wallner BP: PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64(15):5471-80.
PubMed
Variant
0.1 mg
11-776-C100
In stock
90.00 USD

0.025 mg
11-776-C025
Delivery 1 week
45.00 USD
Variant
0.1 mg
11-261-C100
In stock
90.00 USD

0.1 mg
11-261-C100
In stock
45.00 USD

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