Exbio — Research products — Antibodies — CD and related antigens — Anti-Ms CD26 Purified

Anti-Ms CD26 Purified

Regulatory status

RUO

Antigen

CD26

Clone

H194-112

Format

Purified

Reactivity

Mouse

Application

IP, FC (QC tested), IHC(F)

Variant

0.1 mg

11-776-C100

In stock

90.00 USD

0.025 mg

11-776-C025

Delivery 1 week

45.00 USD

Variant

0.1 mg

11-776-C100

In stock

90.00 USD

0.025 mg

11-776-C025

Delivery 1 week

45.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Rat IgG2a kappa

Specificity

The rat monoclonal antibody H194-112 recognizes an extracellular epitope of CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.

Application

IP, FC (QC tested), IHC(F)

Application details

Flow cytometry: Recommended dilution: 1-4 μg/ml.

Reactivity

Mouse

Immunogen

BALB/c thymocytes

Concentration

1 mg/ml

Preparation

Purified by protein-G affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

DPP4, TP103, ADCP-2, ADABP

Antigen description

CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

Entrez Gene ID 13482

UniProt ID P28843

Separation of murine splenocytes stained using anti-mouse CD26 (H194-112) purified antibody (concentration in sample 4 μg/ml, DAR APC, red-filled) from murine splenocytes unstained by primary antibody (DAR APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Niedermeyer J, Kriz M, Hilberg F, Garin-Chesa P, Bamberger U, Lenter MC, Park J, Viertel B, Püschner H, Mauz M, Rettig WJ, Schnapp A: Targeted disruption of mouse fibroblast activation protein. Mol Cell Biol. 2000 Feb;20(3):1089-94.
PubMed

James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D, Simpson E, Cardozo L, Warrens A, Szydlo RM, Lechler RI, Marelli-Berg FM: Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood. 2003 Sep 15;102(6):2173-9.
PubMed

Dorrell C, Erker L, Lanxon-Cookson KM, Abraham SL, Victoroff T, Ro S, Canaday PS, Streeter PR, Grompe M: Surface markers for the murine oval cell response. Hepatology. 2008 Oct;48(4):1282-91.
PubMed

Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N: Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9.
PubMed

Adams S, Miller GT, Jesson MI, Watanabe T, Jones B, Wallner BP: PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64(15):5471-80.
PubMed