Anti-Ms CD106 Purified

Anti-Ms CD106 Purified
Regulatory status
RUO
Antigen
CD106
Clone
429 (MVCAM.A)
Format
Purified
Reactivity
Mouse
Variant
0.1 mg
11-742-C100
Ask for delivery term HERE
88.00 USD

0.025 mg
11-742-C025
Delivery 1 week
44.00 USD
Variant
0.1 mg
11-742-C100
Ask for delivery term HERE
88.00 USD

0.025 mg
11-742-C025
Delivery 1 week
44.00 USD
Product details
Description
Images
References
SDS download
Isotype
Rat IgG2a kappa
Specificity
The rat monoclonal antibody 429 (also known as MVCAM.A) recognizes an extracellular epitope of murine CD106, a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.
Application details
Immunohistochemistry (frozen sections): Acetone fixation.
Flow cytometry: Recommended dilution: 1-4 µg/ml
Reactivity
Mouse
Immunogen
Murine preadipose cell line PA6
Concentration
1 mg/ml
Preparation
Purified by protein-G affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
Vcam-1
Antigen description
CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity.
Entrez Gene ID 22329
UniProt ID Q3UPN1
11-742_FC_Profil Značení
Flow cytometry surface staining pattern of murine bone marrow cell suspension stained using anti-mouse CD160 (429) purified antibody (concentration in sample 0,19 μg/ml) DAR APC.
11-742_FC_Histogram
Separation of murine CD106 positive cells (red-filled) from CD106 negative cells (black-dashed) in flow cytometry analysis (surface staining) of murine bone marrow cell suspension stained using anti-mouse CD160 (429) purified antibody (concentration in sample 0,19 μg/ml) DAR APC.

Product specific references:

Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ: Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol. 2012 Sep 1;189(5):2488-501.
PubMed
Dunzendorfer S, Lee HK, Soldau K, Tobias PS: Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses. FASEB J. 2004 Jul;18(10):1117-9. Epub 2004 May 7.
PubMed
Sacher T, Knolle P, Nichterlein T, Arnold B, Hämmerling GJ, Limmer A: CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes. Eur J Immunol. 2002 Dec;32(12):3628-37.
PubMed
Variant
0.1 mg
11-742-C100
Ask for delivery term HERE
88.00 USD

0.025 mg
11-742-C025
Delivery 1 week
44.00 USD
Variant
0.1 mg
11-742-C100
Ask for delivery term HERE
88.00 USD

0.025 mg
11-742-C025
Delivery 1 week
44.00 USD

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