Exbio — Research products — Antibodies — CD and related antigens — Anti-Ms CD106 Purified

Anti-Ms CD106 Purified

Regulatory status

RUO

Antigen

CD106

Clone

429 (MVCAM.A)

Format

Purified

Reactivity

Mouse

Application

IP, FC (QC tested), IHC(F)

Variant

0.1 mg

11-742-C100

In stock

80.00 USD

0.025 mg

11-742-C025

Delivery 1 week

40.00 USD

Variant

0.1 mg

11-742-C100

In stock

80.00 USD

0.025 mg

11-742-C025

Delivery 1 week

40.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Rat IgG2a kappa

Specificity

The rat monoclonal antibody 429 (also known as MVCAM.A) recognizes an extracellular epitope of murine CD106, a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.

Application

IP, FC (QC tested), IHC(F)

Application details

Immunohistochemistry (frozen sections): Acetone fixation.
Flow cytometry: Recommended dilution: 1-4 µg/ml

Reactivity

Mouse

Immunogen

Murine preadipose cell line PA6

Concentration

1 mg/ml

Preparation

Purified by protein-G affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

Vcam-1

Antigen description

CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity.

Entrez Gene ID 22329

UniProt ID Q3UPN1

Flow cytometry surface staining pattern of murine bone marrow cell suspension stained using anti-mouse CD160 (429) purified antibody (concentration in sample 0,19 μg/ml) DAR APC.

Separation of murine CD106 positive cells (red-filled) from CD106 negative cells (black-dashed) in flow cytometry analysis (surface staining) of murine bone marrow cell suspension stained using anti-mouse CD160 (429) purified antibody (concentration in sample 0,19 μg/ml) DAR APC.

Product specific references:

Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ: Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol. 2012 Sep 1;189(5):2488-501.
PubMed

Dunzendorfer S, Lee HK, Soldau K, Tobias PS: Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses. FASEB J. 2004 Jul;18(10):1117-9. Epub 2004 May 7.
PubMed

Sacher T, Knolle P, Nichterlein T, Arnold B, Hämmerling GJ, Limmer A: CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes. Eur J Immunol. 2002 Dec;32(12):3628-37.
PubMed

Further SDS language mutations available for download below. Please contact us with request for additional languages on info@exbio.cz
MPAbNaN3_SDS_v6_CS.pdf
MPAbNaN3_SDS_v6_EN.pdf

Variant

0.1 mg

11-742-C100

In stock

80.00 USD

0.025 mg

11-742-C025

Delivery 1 week

40.00 USD

Variant

0.1 mg

11-742-C100