Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu TROP2 Biotin

Anti-Hu TROP2 Biotin

Regulatory status

RUO

Antigen

TROP2

Clone

TrMab-6

Format

Biotin

Reactivity

Pig, Human

Application

IHC, WB, FC (QC tested), ICC

Variant

0.1 mg

1B-898-C100

In stock

203.50 USD

Variant

0.1 mg

1B-898-C100

In stock

203.50 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Mouse IgG2b kappa

Specificity

The mouse monoclonal antibody TrMab-6 recognizes an extracellular epitope of TROP2, a type I transmembrane glycoprotein. This antibody is usefull for detection of TROP2 in breast cancer.

Application

IHC, WB, FC (QC tested), ICC

Application details

Flow cytometry: Recommended dilution: 1-4 μg/ml.

Reactivity

Pig, Human

Negative species

Mouse

Immunogen

TROP2-transfected CHO cells

Concentration

1 mg/ml

Preparation

Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

TACSTD2, EGP1, GP50, M1S1, GA733-1

Antigen description

TROP2 is a cell surface receptor that transduces calcium signals. It belongs to carcinoma-associated antigens. Mutations of TROP2 have been associated with gelatinous drop-like corneal dystrophy.

Entrez Gene ID 4070

UniProt ID P09758

Separation of MCF-7 cells stained using anti-TROP2 (TrMab-6) Biotin antibody (concentration in sample 1.0 μg/ml, Streptavidin PE, red-filled) from MCF-7 cells unstained by primary antibody (Streptavidin PE, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Sayama Y, Kaneko MK, Kato Y: Development and characterization of TrMab‑6, a novel anti‑TROP2 monoclonal antibody for antigen detection in breast cancer. Mol Med Rep. 2021 Feb;23(2):92.
PubMed