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Exbio
—
Research products
—
Antibodies
—
CD and related antigens
—
Anti-Hu TCR gamma/delta Purified Low Endotoxin
Anti-Hu TCR gamma/delta Purified Low Endotoxin
Regulatory status
RUO
Antigen
TCR gamma/delta
Clone
B1
Format
Purified Low Endotoxin
Reactivity
Human, Non-human primates
Application
FC (QC tested), IHC(F), IHC(P), FUNC
Variant
0.1 mg
12-147-C100
In stock
143.00 USD
Variant
0.1 mg
12-147-C100
In stock
143.00 USD
Contact distributor
Product details
Description
Images
References
SDS download
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody B1 (also known as B1.1) recognizes an extracellular epitope of TCR gamma/delta, the subtype of T cell receptor expressed mainly in epithelial tissues and at the sites of infection.
Application
FC (QC tested), IHC(F), IHC(P), FUNC
Application details
Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 µg/ml
Reactivity
Human, Non-human primates
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
TCRG/D
Antigen description
The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.
Flow cytometry analysis (surface staining) of human peripheral blood lymphocytes with anti-human TCR gamma/delta (B1) purified antibody (low endotoxin), GAM-APC.
Product specific references:
Pöllinger B, Junt T, Metzler B, Walker UA, Tyndall A, Allard C, Bay S, Keller R, Raulf F, Di Padova F, O'Reilly T, Horwood NJ, Patel DD, Littlewood-Evans A: Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans.
PubMed
Bordignon M, Belloni Fortina A, Pigozzi B, Alaibac M: γδ T cells as potential contributors to the progression of parapsoriasis to mycosis fungoides. Mol Med Rep. 2008 Jul-Aug;1(4):485-8.
PubMed
Correia DV, Fogli M, Hudspeth K, da Silva MG, Mavilio D, Silva-Santos B: Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells. Blood. 2011 Jul 28;118(4):992-1001.
PubMed
Lehmann FS, Terracciano L, Carena I, Baeriswyl C, Drewe J, Tornillo L, De Libero G, Beglinger C: In situ correlation of cytokine secretion and apoptosis in Helicobacter pylori-associated gastritis. Am J Physiol Gastrointest Liver Physiol. 2002 Aug;283(2):G481-8.
PubMed
Rodríguez-Gago M, de Heredia A, Ramírez P, Parrilla P, Aparicio P, Yélamos J: Human anti-porcine gammadelta T-cell xenoreactivity is inhibited by human FasL expression on porcine endothelial cells. Transplantation. 2001 Aug 15;72(3):503-9.
PubMed
Further SDS language mutations available for download below. Please contact us with request for additional languages on info@exbio.cz
MPAb_SDS_v1_GB.pdf
MPAb_SDS_v1_TR.pdf
MPAb_SDS_v6_AT.pdf
MPAb_SDS_v6_CH.pdf
MPAb_SDS_v6_CS.pdf
MPAb_SDS_v6_EN.pdf
MPAb_SDS_v6_ES.pdf
MPAb_SDS_v6_FR.pdf
MPAb_SDS_v6_IT.pdf
MPAb_SDS_v6_NO.pdf
MPAb_SDS_v6_PL.pdf
MPAb_SDS_v6_PT.pdf
MPAb_SDS_v6_SE.pdf
MPAb_SDS_v6_SK.pdf
MPAb_SDS_v6_SL.pdf
MPAb_SDS_v7_DE.pdf
Variant
0.1 mg
12-147-C100
In stock
143.00 USD
Variant
0.1 mg
12-147-C100
In stock
143.00 USD
Contact distributor
Datasheet download
Bulk requests
Technical support for this product
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