Anti-Hu LOX1 Purified

Anti-Hu LOX1 Purified
Regulatory status
RUO
Antigen
LOX1
Clone
15C4
Format
Purified
Reactivity
Human
Variant
0.1 mg
11-929-C100
Ask for delivery term HERE
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG2a kappa
Specificity
The mouse monoclonal antibody 15C4 recognizes an extracellular epitope of LOX1, a C-type lectin transmembrane protein.
Application details
Flow cytometry: Recommended dilution: 1-5 µg/ml
Reactivity
Human
Immunogen
fusion protein of human LOX1 ectodomain and of human IgG Fc
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
OLR1, SLOX1, SCARE1, CLEC8A
Antigen description
LOX1, a 31 kDa type II transmembrane protein, is a C-type lectin, functioning as a scavenger receptor for e.g. oxidized low density lipoprotein, apoptotic heat shock proteins, or CRP. It is expressed by macrophages, fibroblasts, platelets, endothelial cells, and smooth muscle cells, and its defects can lead to atherosclerosis. Its expression is enhanced under inflammatory conditions. Multiple splicing variants have been identified.
Entrez Gene ID 4973
UniProt ID P78380
11-929_FC_Profil značení
Flow cytometry surface staining pattern of human dendritic cells in flow cytometry analysis (surface staining) stained using anti-human LOX1 (15C4) purified antibody (concentration in sample 5 μg/ml, GAM APC).
11-929_FC_Histogram
Separation of human dendritic cells (red-filled) from human lymphocytes (black-dashed) in flow cytometry analysis (surface staining) stained using anti-human LOX1 (15C4) purified antibody (concentration in sample 5 μg/ml, GAM APC).

Product specific references:

Duluc D, Banchereau R, Gannevat J, Thompson-Snipes L, Blanck JP, Zurawski S, Zurawski G, Hong S, Urgell JR, Pascual V, Baldwin N, Stecher J, Carley M, Boreham M, Oh S: Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments. Genome Med. 2014 Nov 25;6(11):98.
PubMed
Cassetta L, Bruderek K, Skrzeczynska J, Osiecka O, Hu X, Rundgren IM, Lin A, Santegoets K, Horzum U, Godinho-Santos A, Zelinsky G, Garcia-Tellez T, Bjelica S, Taciak B, Kittang AO, Höing B, Lang S, Dixon M, Müller V, Utíkal JS, Karakoç D, Yilmaz KB, Górka E, Bodnár L, Anastasiou OE, Bourgeois C, Baďura R, Kapinska-Mrowiecka M, Gotic M, Laan MT, Kers-Rebel E, Król M, Santibañez JF, Müller M, Dittmer U, de Sousa AE, Esendağli G, Adema G, Loré K, Ersvær E, Umansky V, Pollard JW, Cichy J, Brandau S: Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation. J Immunother Cancer. 2020 Sep;8(2):e001223.
PubMed
Joo H, Li D, Dullaers M, Kim TW, Duluc D, Upchurch K, Xue Y, Zurawski S, Le Grand R, Liu YJ, Kuroda M, Zurawski G, Oh S: C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. Immunity 2014 Oct 16;41(4):592-604.
PubMed
Bayik D, Zhou Y, Park C, Hong C, Vail D, Silver DJ, Lauko A, Roversi G, Watson DC, Lo A, Alban TJ, McGraw M, Sorensen M, Grabowski MM, Otvos B, Vogelbaum MA, Horbinski C, Kristensen BW, Khalil AM, Hwang TH, Ahluwalia MS, Cheng F, Lathia JD: Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner. Cancer Discov. 2020 Aug;10(8):1210-1225.
PubMed
Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J, Oh S: Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med. 2012 Jan 16;209(1):109-21.
PubMed
Variant
0.1 mg
11-929-C100
Ask for delivery term HERE
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD

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