Anti-Hu LAR APC

Anti-Hu LAR APC
Regulatory status
RUO
Antigen
LAR
Clone
W7C6
Format
APC
Reactivity
Non-human primates, Human
Application
Excitation laser
red (633 nm)
Variant
0.1 mg
1A-830-C100
In stock
220.00 USD
Variant
0.1 mg
11-261-C100
In stock
220.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody W7C6 recognizes an extracellular epitope of protein tyrosine phosphatase LAR, a marker of mesenchymal stem cells.
Application
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Non-human primates, Human
Immunogen
WERI-RB-1 retinoblastoma cells
Concentration
0.1 mg/ml
Preparation
The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage and handling
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
Leucocyte common antigen related molecule, PTPRF, W7C6
Antigen description
LAR is a receptore-linked transmembrane protein tyrosine phosphatase expressed on mesenchymal stem cells, that reside e.g. in bone marrow, blood, placenta, adipose tissue, or skin, as well as it is expressed on some carcinoma cell lines, including HeLa, MCF-7, or HT29. During the process of externalization, LAR is intracellularly proteolytically processed into two non-covalently associated subunits. This protein is involved in intercellular and cell-matrix interactions and its extracellular part resembles that of cell adhesion molecules (CAMs). The extracellular part can be released from the surface, which may be used for regulation of LAR function.
Entrez Gene ID 5792
UniProt ID G1UI20
1A-830_FC_Histogram
Separation of HeLa cells stained using anti-human LAR (W7C6) APC antibody (concentration in sample 1,7 μg/ml, red-filled) from HeLa cells stained using mouse IgG1 isotype control (MOPC-21) APC antibody (concentration in sample 1,7 μg/ml, same as LAR APC concentration, black-dashed) in flow cytometry analysis (surface staining) of HeLa cell suspension.

Product specific references:

Bühring HJ, Battula VL, Treml S, Schewe B, Kanz L, Vogel W: Novel markers for the prospective isolation of human MSC. Ann N Y Acad Sci. 2007 Jun;1106:262-71.
PubMed
Variant
0.1 mg
1A-830-C100
In stock
220.00 USD
Variant
0.1 mg
11-261-C100
In stock
220.00 USD

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