Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu CD85h Purified

Anti-Hu CD85h Purified

Regulatory status

RUO

Antigen

CD85h

Clone

Format

Purified

Reactivity

Non-human primates, Human

Application

FC (QC tested), IHC(F)

Variant

0.1 mg

11-925-C100

In stock

154.00 USD

Variant

0.1 mg

11-925-C100

In stock

154.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Mouse IgG2b kappa

Specificity

The mouse monoclonal antibody 24 recognizes an extracellular epitope of CD85h, an approximately 70 kDa transmembrane glycoprotein.

Application

FC (QC tested), IHC(F)

Application details

Flow cytometry: Recommended dilution: 1-4 μg/ml.

Reactivity

Non-human primates, Human

Immunogen

human CD85h transfectants

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

ILT1, LIR7, LILRA2

Antigen description

CD85h (leukocyte Ig-like receptor A2) is a type I transmembrane glycoprotein, associating with Fc receptor gamma chain, to serve as an activating immunoreceptor. In the result, however, CD85h signaling leads to suppression of dendritic cell differentiation and antigen presentation, and of innate immune responses. This glycoprotein is expressed mainly on monocytes, macrophages, and myeloid dendritic cells, at a lower level on granulocyte and NK cell subsets.

Entrez Gene ID 11027

UniProt ID Q8N149

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD85h (24) purified antibody (concentration in sample 0,56 μg/ml, GAM APC).

Separation of human monocytes (red-filled) from human lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of peripheral whole blood stained using anti-human CD85h (24) purified antibody (concentration in sample 0,56 μg/ml, GAM APC).

Product specific references:

Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL: LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15;179(12):8128-36.
PubMed