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Exbio
—
Research products
—
Antibodies
—
CD and related antigens
—
Anti-Hu CD68 Purified
Anti-Hu CD68 Purified
Regulatory status
RUO
Antigen
CD68
Clone
Y1/82A
Format
Purified
Reactivity
Human
Application
FC (QC tested), IHC(F)
Variant
0.1 mg
11-749-C100
In stock
130.00 USD
0.025 mg
11-749-C025
Delivery 1 week
65.00 USD
Variant
0.1 mg
11-749-C100
In stock
130.00 USD
0.025 mg
11-749-C025
Delivery 1 week
65.00 USD
Contact distributor
Product details
Description
Images
References
Isotype
Mouse IgG2b
Specificity
The mouse monoclonal antibody Y1/82A recognizes CD68 (LAMP4), a 110 kDa glycoprotein expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells.
Workshop
HLDA IV, HLDA VI
Application
FC (QC tested), IHC(F)
Application details
Flow cytometry: Recommended dilution: 2-6 μg/ml. Extracellular and intracellular staining.
Reactivity
Human
Immunogen
Lysosomal contents of lung macrophages
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
GP110, LAMP4, SCARD1
Antigen description
CD68 (also known as LAMP4 or SCARD1) is a 110 kDa type I transmembrane glycoprotein of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and the scavenger receptor family. Although CD68 primarily localizes to lysosomes and endosomes, its fraction circulates to the cell surface. By the heavily glycosylated extracellular domain CD68 binds to tissue- and organ-specific lectins or selectins. It is expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells, but also e.g. in a proportion of epithelial tumours (diagnosis of poorly differentiated neoplasms).
Entrez Gene ID
968
UniProt ID
P34810
Flow cytometry intracellular staining pattern of human peripheral blood stained using anti-human CD68 (Y1/82A) purified antibody (concentration in sample 2 μg/ml) GAM FITC.
Separation of human monocytes (red-filled) from CD68 negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD68 (Y1/82A) purified antibody (concentration in sample 2 μg/ml) GAM FITC.
Product specific references:
Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non-macrophage derived tumours in cytological specimens. J Clin Pathol. 1993 Apr;46(4):334-6.
PubMed
Ulanova M, Tarkowski A, Hahn-Zoric M, Hanson LA: The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism. Infect Immun. 2001 Feb;69(2):1151-9.
PubMed
Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD: Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res. 2004 Jul;56(1):79-87.
PubMed
I A Doussis, K C Gatter, and D Y Mason: CD68 reactivity of non-macrophage derived tumours in cytological specimens. J Clin Pathol. 1993 April; 46(4): 334–336.
PubMed
Yamagami S, Yokoo S, Amano S, Ebihara N: Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4476-81.
PubMed
Holness CL, Simmons DL: Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 1993 Mar 15;81(6):1607-13.
PubMed
Variant
0.1 mg
11-749-C100
In stock
130.00 USD
0.025 mg
11-749-C025
Delivery 1 week
65.00 USD
Variant
0.1 mg
11-749-C100
In stock
130.00 USD
0.025 mg
11-749-C025
Delivery 1 week
65.00 USD
Contact distributor
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SDS download
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