Anti-Hu CD66c Purified

Anti-Hu CD66c Purified
Regulatory status
RUO
Antigen
CD66c
Clone
B6.2
Format
Purified
Reactivity
Human
Variant
0.1 mg
11-863-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody B6.2 recognizes a conformationally dependent epitope of native CD66c, a GPI-anchored extracellular glycoprotein expressed on granulocytes and epithelial cells.
Workshop
HLDA V: MA135, HLDA VI: MA86
Application details
Flow cytometry: Recommended dilution: 3-12 µg/ml
Reactivity
Human
Immunogen
Extracts from human breast carcinoma cells
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
CEAL, NCA, CEACAM6
Antigen description
CD66c is a GPI-anchored glycoprotein capable of homophilic adhesion and heterophilic binding to CD66a-e, CD62E, and galectins. It is expressed on granulocytes and epithelial cells, and has potential applications in the detection of sites of infection and inflammation.
Entrez Gene ID 4680
UniProt ID P40199
11-863_FC_Profil značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD66c (B6.2) purified antibody (concentration in sample 3 μg/ml, GAM APC).
11-863_FC_Histogram
Separation of neutrophil granulocytes stained anti-human CD66c (B6.2) purified antibody (concentration in sample 3 μg/ml, GAM APC, red-filled) from neutrophil granulocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Szpak CA, Johnston WW, Lottich SC, Kufe D, Thor A, Schlom J: Patterns of reactivity of four novel monoclonal antibodies (B72.3, DF3, B1.1 and B6.2) with cells in human malignant and benign effusions. Acta Cytol. 1984 Jul-Aug;28(4):356-67.
PubMed
Yamagami S, Yokoo S, Amano S, Ebihara N: Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4476-81.
PubMed
Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA: Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood. 2001 Sep 1;98(5):1469-79.
PubMed
Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K: Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. J Biol Chem. 2008 Jun 6;283(23):15647-55.
PubMed
Variant
0.1 mg
11-863-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD