Anti-Hu CD49e Purified

Anti-Hu CD49e Purified
Regulatory status
RUO
Antigen
CD49e
Clone
SAM1
Format
Purified
Reactivity
Non-human primates, Human
Variant
0.1 mg
11-914-C100
Ask for delivery term HERE
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG2b
Specificity
The mouse monoclonal antibody SAM1 recognizes an extracellular epitope of CD49e (integrin 5 alpha), a transmembrane glycoprotein expressed on thymocytes, early and activated B cells, monocytes, NK cells, dendritic cells, osteoblast and endothelial cells.
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Non-human primates, Human
Immunogen
U937 cells
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
VLA5 alpha, integrin 5 alpha, FNRA
Antigen description
CD49e (VLA5 alpha) is a type I transmembrane glycoprotein of the integrin alpha subclass (intergrin 5 alpha), expressed on thymocytes, early and activated B cells, monocytes, NK cells, dendritic cells, osteoblast and endothelial cells. It binds to RGD sequence in fibronectin and to neural adhesion molecule L1. CD49e interactions are important for maintaining the integrity of the endothelial monolayer, as well as it is involved in monocyte migration, T cell costimulation, regulation of cell survival, and other.
Entrez Gene ID 3678
UniProt ID P08648
11-914_FC_Profil značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD49e (SAM1) purified antibody (concentration in sample 1,7 μg/ml, GAM APC).
11-914_FC_Histogram
Separation of human CD49e positive monocytes (red-filled) from human CD49e negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of peripheral whole blood stained using anti-human CD49e (SAM1) purified antibody (concentration in sample 1,7 μg/ml, GAM APC).

Product specific references:

Blase L, Merling A, Engelmann S, Möller P, Schwartz-Albiez R: Characterization of cell surface-expressed proteochondroitin sulfate of pre-B Nalm-6 cells and its possible role in laminin adhesion. Leukemia 1996 Jun;10(6):1000-11.
PubMed
Tachimoto H, Hudson SA, Bochner BS: Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation. J Allergy Clin Immunol. 2001 Feb;107(2):302-9
PubMed
Malara A, Gruppi C, Rebuzzini P, Visai L, Perotti C, Moratti R, Balduini C, Tira ME, Balduini A: Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A. Blood 2011 Feb 24;117(8):2476-83.
PubMed
Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J: Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril. 1994 Sep;62(3):497-506.
PubMed
Variant
0.1 mg
11-914-C100
Ask for delivery term HERE
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD

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