Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu CD49c Purified

Anti-Hu CD49c Purified

Anti-Hu CD49c Purified
Regulatory status
RUO
Antigen
CD49c
Clone
ASC-1
Format
Purified
Reactivity
Human
Application
IP, WB, FC (QC tested), IHC(F)
Variant
0.1 mg
11-137-C100
In stock
130.00 USD
0.025 mg
11-137-C025
Ask for delivery term HERE
65.00 USD
Variant
0.1 mg
11-261-C100
In stock
130.00 USD
0.1 mg
11-261-C100
In stock
65.00 USD
Contact distributor
Product details
Description
Images
References
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody ASC-1 recognizes an extracellular epitope of CD49c (integrin alpha 3), a transmembrane glycoprotein composed of disulfide linked 125 kDa and 30 kDa chains, and expressed on adherent cell lines and to a lesser extent on T and B cells and monocytes.
Workshop
HLDA VI: WS Code A002
Application
IP, WB, FC (QC tested), IHC(F)
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Human
Immunogen
Human SSC-9 cell line (squamous cell carcinoma)
Other names
ITGA3, VLA-3 alpha, FRP-2, FRP2, GAPB3
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
ITGA3, VLA-3 alpha, FRP-2, FRP2, GAPB3
Antigen description
CD49c / Integrin alpha 3 is a type I transmembrane glycoprotein proteolytically cleaved into two disulfide linked chains. It noncovalently associates with CD29 (integrin beta 1) to form the VLA-3 complex, an adhesion receptor for extracellular matrix components (fibronectin, laminin 1, laminin 5, entactin, and collagen). It is expressed on adherent cells, mainly on fibroblasts, epithelial cells and endothelial cells.
Entrez Gene ID 3675
UniProt ID P26006
11-137 FC
Separation of HeLa cells stained using anti-human CD49c (ASC-1) purified antibody (concentration in sample 16 μg/ml, GAM APC, red) from HeLa cells unstained by primary antibody (GAM APC, black) in flow cytometry analysis (surface staining).

Product specific references:

Skubitz AP, Bast RC, Wayner EA, Letourneau PC, Wilke MS: Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol. 1996 May;148(5):1445-61.
PubMed
Pattaramalai S, Skubitz KM, Skubitz AP: A novel recognition site on laminin for the alpha 3 beta 1 integrin. Exp Cell Res. 1996 Feb 1;222(2):281-90.
PubMed
Variant
0.1 mg
11-137-C100
In stock
130.00 USD
0.025 mg
11-137-C025
Ask for delivery term HERE
65.00 USD
Variant
0.1 mg
11-261-C100
In stock
130.00 USD
0.1 mg
11-261-C100
In stock
65.00 USD
Contact distributor
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