Anti-Hu CD42b Purified

Anti-Hu CD42b Purified
Regulatory status
RUO
Antigen
CD42b
Clone
HIP1
Format
Purified
Reactivity
Non-human primates, Human
Variant
0.1 mg
11-367-C100
In stock
140.00 USD

0.025 mg
11-367-C025
Delivery 1 week
70.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD

0.1 mg
11-261-C100
In stock
70.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The antibody HIP1 reacts with an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
Workshop
HLDA IV: WS Code P 40
Application details
Flow cytometry: Recommended dilution: 1-4 µg/ml
Reactivity
Non-human primates, Human
Immunogen
Peripheral blood mononuclear cells of a patient suffering with CLL.
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3
Antigen description
CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Entrez Gene ID 2811
UniProt ID P07359
11-367_FC_Profil Značení
Flow cytometry surface staining pattern of human peripheral blood cells stained using anti-human CD42b (HIP1) purified antibody (concentration in sample 4 μg/ml) GAM APC.
11-367_FC_Histogram
Separation of human thrombocytes (red-filled) from CD42b negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD42b (HIP1) purified antibody (concentration in sample 4 μg/ml) GAM APC.

General references:

Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD: The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16900-5.
PubMed
Vanhoorelbeke K, Ulrichts H, Van de Walle G, Fontayne A, Deckmyn H: Inhibition of platelet glycoprotein Ib and its antithrombotic potential. Curr Pharm Des. 2007;13(26):2684-97.
PubMed
Jain S, Zuka M, Liu J, Russell S, Dent J, Guerrero JA, Forsyth J, Maruszak B, Gartner TK, Felding-Habermann B, Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9024-8.
PubMed

Product specific references:

Leukocyte Typing IV., Knapp W et al. (Eds.), Oxford University Press (1989).
Takahashi R, Sekine N, Nakatake T: Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Blood. 1999 Mar 15;93(6):1951-8.
PubMed
Variant
0.1 mg
11-367-C100
In stock
140.00 USD

0.025 mg
11-367-C025
Delivery 1 week
70.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD

0.1 mg
11-261-C100
In stock
70.00 USD

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