Anti-Hu CD39 PE

Anti-Hu CD39 PE
Regulatory status
RUO
Antigen
CD39
Clone
TU66
Format
PE
Reactivity
Human
Application
FC (QC tested)
Excitation laser
blue (488 nm)
Variant
100 tests
1P-184-T100
In stock

25 tests
1P-184-T025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock
Product details
References
Isotype
Mouse IgG2b kappa
Specificity
The mouse monoclonal antibody TU66, also known as Tü66, recognizes CD39, a 78 kDa cell surface enzyme expressed by regulatory T cells, mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets.
Workshop
HLDA IV: WS Code A54
Application
FC (QC tested)
Application details
Flow cytometry: The reagent is designed for analysis of human blood cells using 5 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.5 ml) is sufficient for 100 tests.
Reactivity
Human
Other names
ETDH1, NTPDase 1, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Lymphoid cell activation antigen, Ecto-apyrase
Preparation
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide
Storage and handling
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Exbio licence note
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic use. In vivo diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s. © 2019 EXBIO Praha, a.s. All rights reserved.

Product specific references:

Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Höpner S, Centonze D, Bernardi G, Dell'Acqua ML, Rossini PM, Battistini L, Rötzschke O, Falk K: Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007 Aug 15;110(4):1225-32.
PubMed
Nikolova M, Carriere M, Jenabian MA, Limou S, Younas M, Kök A, Huë S, Seddiki N, Hulin A, Delaneau O, Schuitemaker H, Herbeck JT, Mullins JI, Muhtarova M, Bensussan A, Zagury JF, Lelievre JD, Lévy Y: CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog. 2011 Jul;7(7):e1002110.
PubMed
Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI: Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep;42(9):2441-51.
PubMed
Gadeock S, Tran JN, Georgiou JG, Jalilian I, Taylor RM, Wiley JS, Sluyter R: TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochim Biophys Acta. 2010 Nov;1798(11):2058-66.
PubMed
Jin Z, Teramoto N, Hayashi K, Liu YX, Jin G, Oka T, Takahashi K, Yoshino T, Akagi T: CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines. Anticancer Res. 2004 Mar-Apr;24(2B):691-7.
PubMed
Variant
100 tests
1P-184-T100
In stock

25 tests
1P-184-T025
Out of stock
Variant
0.1 mg
11-261-C100
In stock

0.1 mg
11-261-C100
In stock