Anti-Hu CD354 Purified

Anti-Hu CD354 Purified
Regulatory status
RUO
Antigen
CD354
Clone
6B1
Format
Purified
Reactivity
Human
Variant
0.1 mg
11-933-C100
In stock
154.00 USD
Variant
0.1 mg
11-933-C100
In stock
154.00 USD
Product details
Description
Images
References
SDS download
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody 6B1 (also known as 6B1.1G12) recognizes an extracellular epitope of human CD354 (TREM-1), a transmembrane glycoprotein, serving as an important innate immunity receptor.
Application details
Flow cytometry: Recommended dilution: 1-4 µg/ml.
Reactivity
Human
Immunogen
recombinant human CD354 fused with IgG
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
TREM-1
Antigen description
CD354 (TREM-1), a cell surface glycoprotein expressed mainly on monocytes, macrophages, and neutrophils, but also on e.g. endothelial cells or bronchial epithelium, plays an important role in innate immune responses. Upon triggering by its ligands (mainly bacterial and fungal components, but also some viruses, such as Marburg or Ebola virus), it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines. CD354 is strongly present in infectious inflammatory lesions (e.g. in folliculitis or impetigo), but not so much in non-infectious inflammatory lesions, (e.g. vasculitis or psoriasis). However, under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions, e.g. in rheumatoid arthritis. Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients, as well as for prediction of their survival.
Entrez Gene ID 54210
UniProt ID Q9NP99
11-933_FC_Profil značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD354 (6B1) purified antibody (concentration in sample 1,67 μg/ml, GAM APC).
11-933_FC_Histogram
Separation of human neutrophil granulocytes (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD354 (6B1) purified antibody (concentration in sample 1,67 μg/ml, GAM APC).

Product specific references:

Kuemmel A, Alflen A, Schmidt LH, Sebastian M, Wiewrodt R, Schulze AB, Buhl R, Radsak M: Soluble triggering receptor expressed on myeloid cells 1 in lung cancer. Sci Rep. 2018 Jul 17;8(1):10766.
PubMed
Alflen A, Stadler N, Lopez PA, Teschner D, Theobald M, Heß G, Radsak MP: Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses. Sci Rep. 2018 Apr 3;8(1):5558.
PubMed
Prüfer S, Weber M, Sasca D, Teschner D, Wölfel C, Stein P, Stassen M, Schild H, Radsak MP: Distinct signaling cascades of TREM-1, TLR and NLR in neutrophils and monocytic cells. J Innate Immun. 2014;6(3):339-52.
PubMed
Hasibeder A, Stein P, Brandwijk R, Schild H, Radsak MP: Evaluation and validation of the detection of soluble triggering receptor expressed on myeloid cells 1 by enzyme-linked immunosorbent assay. Sci Rep. 2015 Oct 20;5:15381.
PubMed
Variant
0.1 mg
11-933-C100
In stock
154.00 USD
Variant
0.1 mg
11-933-C100
In stock
154.00 USD

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