Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu CD319 Purified

Anti-Hu CD319 Purified

Regulatory status

RUO

Antigen

CD319

Clone

162

Format

Purified

Reactivity

Human

Application

IP, FC (QC tested), IHC(P)

Variant

0.1 mg

11-908-C100

In stock

154.00 USD

Variant

0.1 mg

11-908-C100

In stock

154.00 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Mouse IgG2b

Specificity

The mouse monoclonal antibody 162 recognizes an extracellular epitope of human CD319, a transmembrane glycoprotein expressed by cytotoxic T cells, activated B cells, NK cells, and mature dendritic cells.

Application

IP, FC (QC tested), IHC(P)

Application details

Flow cytometry: Recommended dilution: 1-4 μg/ml.

Reactivity

Human

Immunogen

Recombinant extracellular domain of human CD319 (204 aa) fused with Fc part of human IgG1

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

SLAMF7, 19A, CS1, CRACC

Antigen description

CD319 is a homophilic type I transmembrane protein with two intracellular immunoreceptor tyrosine-based switch motives (ITSMs). It is expressed by cytotoxic T cells, activated B cells and plasma cells, NK cells, and mature dendritic cells. CD319 triggers NK cell-mediated cytotoxicity. Ligation of CD319 can induce proliferation, cell adhesion, cytokine secretion, and cytotoxicity of T cells and NK cells.

Entrez Gene ID 57823

UniProt ID Q9NQ25

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD319 (162) purified antibody (concentration in sample 1,7 μg/ml, GAM APC).

Separation of human CD319 positive lymphocytes (red-filled) from CD319 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD319 (162) purified antibody (concentration in sample 1,7 μg/ml, GAM APC).

Product specific references:

Chan WK, Kang S, Youssef Y, Glankler EN, Barrett ER, Carter AM, Ahmed EH, Prasad A, Chen L, Zhang J, Benson DM Jr, Caligiuri MA, Yu J: A CS1-NKG2D bispecific antibody collectively activates cytolytic immune cells against multiple myeloma. Cancer Immunol Res. 2018 Jul;6(7):776-787.
PubMed