Anti-Hu CD307c Purified

Anti-Hu CD307c Purified
Regulatory status
RUO
Antigen
CD307c
Clone
H5
Format
Purified
Reactivity
Human
Application
Variant
0.1 mg
11-858-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG2b kappa
Specificity
The mouse monoclonal antibody H5 recognizes an epitope within extracellular part of CD307c, a transmembrane glycoprotein expressed mainly on NK cells, and T and B cell subsets.
Workshop
HLDA IX
Application
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Human
Immunogen
DNA-immunization followed by a boost with CD307c transfected cells
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
FcRL3, IRTA3
Antigen description
CD307c is a type I transmembrane glycoprotein of the Fc receptor family. It contains both ITAM and ITIM motifs in its cytoplasmic domain. CD307c is expressed on the surface of NK cells, and T, Treg, B and plasma cell subsets. It seems to play a role in the regulation of immune response. Defects in CD307c function can result in autoimmune diseases, e.g. rheumatoid arthritis or systemic lupus erythematosus.
Entrez Gene ID 115352
UniProt ID Q96P31
11-858_FC_dot plot
Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD19 (LT19) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD307c (H5) purified antibody (1,7 μg/ml, GAM-FITC).

Product specific references:

Jourdan M, Robert N, Cren M, Thibaut C, Duperray C, Kassambara A, Cogné M, Tarte K, Klein B, Moreaux J: Characterization of human FCRL4-positive B cells. PLoS One. 2017 Jun 21;12(6):e0179793.
PubMed
Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH: CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients. J Invest Dermatol. 2014 Jan;134(1):229-236.
PubMed
Nagata S, Ise T, Pastan I: Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009 Jun 15;182(12):7518-26
PubMed
Variant
0.1 mg
11-858-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD