Anti-Hu CD270 Purified

Anti-Hu CD270 Purified
Regulatory status
RUO
Antigen
CD270
Clone
CW10
Format
Purified
Reactivity
Human
Variant
0.1 mg
11-911-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody CW10 recognizes an extracellular epitope on CD270, a type I transmembrane protein expressed on resting T cells, monocytes, and immature dendritic cells.
Application details
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Reactivity
Human
Immunogen
recombinant human CD270
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
TNFRSF14, TR2, ATAR, HVEA, HVEM, LIGHTR
Antigen description
CD270 is a type I transmembrane protein of the TNFR superfamily, which is expressed on resting T cells, monocytes, and immature dendritic cells. Its ligands, CD258 and CD272, differ in effect on CD270 signaling. Whereas binding to CD258 provides a costimulatory signal, binding to CD272 gives to the cell an inhibitory signal. CD270 also is recognized by herpes simplex glycoprotein D. CD258-CD270 interaction and signaling is implicated in macrophage-derived foam cell-mediated development of atherosclerotic lesions.
Entrez Gene ID 8764
UniProt ID Q92956
11-911_FC_Histogram
Separation of HDLM-2 cells stained using anti-CD270 (CW10) purified antibody (concentration in sample 1,6 μg/ml, GAM APC, red-filled) from HDLM-2 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Whitbeck JC, Connolly SA, Willis SH, Hou W, Krummenacher C, de Leon MP, Lou H, Baribaud I, Eisenberg RJ, Cohen GH: Localization of the gD-binding region of the human herpes simplex virus receptor, HveA. J Virol. 2001 Jan;75(1):171-80.
PubMed
Stiles KM, Whitbeck JC, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C: Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition. J Virol. 2010 Nov;84(22):11646-60.
PubMed
Variant
0.1 mg
11-911-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD

Related products

-134%
Reg. statusCE IVD
ApplicationFC
100 ml
200.00 USD
-134%
Reg. statusCE IVD
ApplicationFC
100 ml
60.00 USD
-134%
Reg. statusRUO
ApplicationFC
100 ml
50.00 USD
-134%
CloneMOPC-21
Reg. statusRUO
0.1 mg
105.00 USD