Anti-Hu CD267 PE

Anti-Hu CD267 PE
Regulatory status
RUO
Antigen
CD267
Clone
1A1
Format
PE
Reactivity
Human
Application
Excitation laser
blue (488 nm)
Variant
100 tests
1P-162-T100
Ask for delivery term HERE
242.00 USD

25 tests
1P-162-T025
Delivery 1 week
121.00 USD
Variant
100 tests
1P-162-T100
Ask for delivery term HERE
242.00 USD

25 tests
1P-162-T025
Delivery 1 week
121.00 USD
Product details
Description
Images
References
SDS download
Isotype
Rat IgG2a kappa
Specificity
The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
Workshop
HLDA VIII
Application
Application details
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity
Human
Immunogen
CD267-transfected RBL cells
Preparation
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
RYZN, TACI, CVID2, IGAD2, TNFRSF14B
Antigen description
CD267 / TACI (transmembrane activator calcium modulator and cyclophilin ligand interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency.
Entrez Gene ID 23495
UniProt ID O14836
1P-162_FC_Profil Značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD267 (1A1) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).
1P-162_FC_Dot-plot
Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD267 (1A1) PE antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD19 (LT19) APC antibody (10 μl reagent / 100 μl of peripheral whole blood).
1P-162_FC_Histogram
Separation of human CD267 positive B cells (red-filled) from CD267 negative CD19 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD267 (1A1) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).

Product specific references:

Koarada S, Tada Y, Suematsu R, Soejima S, Inoue H, Ohta A, Nagasawa K: Phenotyping of P105-negative B cell subsets in patients with systemic lupus erythematosus. Clin Dev Immunol. 2012;2012:198206.
PubMed
Variant
100 tests
1P-162-T100
Ask for delivery term HERE
242.00 USD

25 tests
1P-162-T025
Delivery 1 week
121.00 USD
Variant
100 tests
1P-162-T100
Ask for delivery term HERE
242.00 USD

25 tests
1P-162-T025
Delivery 1 week
121.00 USD

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